Author, as appears in the article.: Guardia-Escote, Laia; Basaure, Pia; Peris-Sampedro, Fiona; Biosca-Brull, Judit; Cabre, Maria; Sanchez-Santed, Fernando; Domingo, Jose L; Teresa Colomina, Maria
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia
URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Keywords: Sex factors Sex characteristics Scopolamine Recognition, psychology Recognition memory Reaction time Pesticide Mice, transgenic Mice, inbred c57bl Mice Memory Maze learning Male Genotype Genetic predisposition to disease Gabaergic neurons Female Exploratory behavior Disease susceptibility Cholinergic system Cholinergic neurons Cholinergic agents Chlorpyrifos Brain development Apolipoproteins e Apolipoprotein e4 Apolipoprotein e3 Apoe Animals pesticide cholinergic system chlorpyrifos brain development apoe
Abstract: © 2019 Elsevier B.V. Chlorpyrifos (CPF) is an extensively used organophosphate pesticide. Exposure to CPF has been related to neurobehavioral disorders, particularly during neurodevelopment. Apolipoprotein E (apoE) is a lipid and cholesterol carrier and a susceptibility factor for cognitive impairment which can influence the response to toxic exposures. The study was aimed at assessing the effects of postnatal exposure to CPF on object recognition memory and its modulation by sex and APOE genotype. Human apoE3 and apoE4 targeted replacement mice and C57BL/6 mice were postnatally exposed to 0 or 1 mg/kg/day of CPF. Recognition memory was evaluated in an Object Recognition Test (ORT). In order to study the contribution of cholinergic and GABAergic neurotransmitter systems to recognition memory, a pharmacological challenge was included. Sex, genotype and postnatal exposure to CPF were key factors throughout the testing period. Specifically, CPF increased exploratory behavior and impaired discrimination performance. We observed that administering scopolamine, a cholinergic antagonist, was detrimental to recognition memory. However, discrimination in C57BL/6 and apoE4 males improved with the administration of the cholinergic agonist rivastigmine, but the same drug worsened retention in apoE4 females. Finally, the GABAergic agonist alprazolam altered performance in a sex- and genotype-dependent manner. Overall, these results suggest complex interactions between sex, APOE genotype and postnatal CPF exposure and indicate a different functioning of both the cholinergic and GABAergic neurotransmitter system between groups.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01664328
Author's mail: maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat
Author identifier: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Behavioural Brain Research. 376 (112195): 112195-112195
APA: Guardia-Escote, Laia; Basaure, Pia; Peris-Sampedro, Fiona; Biosca-Brull, Judit; Cabre, Maria; Sanchez-Santed, Fernando; Domingo, Jose L; Teresa Colomi (2019). APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs. Behavioural Brain Research, 376(112195), 112195-112195. DOI: 10.1016/j.bbr.2019.112195
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV