Author, as appears in the article.: Gea, Alfredo; Beunza, Juan J; Estruch, Ramon; Sanchez-Villegas, Almudena; Salas-Salvado, Jordi; Buil-Cosiales, Pilar; Gomez-Gracia, Enrique; Covas, Maria-Isabel; Corella, Dolores; Fiol, Miquel; Aros, Fernando; Lapetra, Jose; Lamuela-Raventos, Rosa-Maria; Waernberg, Julia; Pinto, Xavier; Serra-Majem, Lluis; Martinez-Gonzalez, Miguel A
Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Fernández Ballart, Joan Domènech / Martín Lujan, Francisco Manuel / Salas Salvadó, Jorge
Keywords: Wine Major depression Depression Cohort Alcohol
Abstract: Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.Moderate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).Moderate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.
Thematic Areas: Saúde coletiva Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i General medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17417015
Author's mail: juanjose.cabre@urv.cat paco.martin@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-1082-6861 0000-0003-0359-3588 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Medicine. 11 (1): 192-NA
APA: Gea, Alfredo; Beunza, Juan J; Estruch, Ramon; Sanchez-Villegas, Almudena; Salas-Salvado, Jordi; Buil-Cosiales, Pilar; Gomez-Gracia, Enrique; Covas, Ma (2013). Alcohol intake, wine consumption and the development of depression: the PREDIMED study. Bmc Medicine, 11(1), 192-NA. DOI: 10.1186/1741-7015-11-192
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications