Author, as appears in the article.: Ceperuelo-Mallafre, Victoria; Llaurado, Gemma; Keiran, Noelia; Benaiges, Ester; Astiarraga, Brenno; Martinez, Laia; Pellitero, Silvia; Miguel Gonzalez-Clemente, Jose; Rodriguez, Amaia; Manuel Fernandez-Real, Jose; Lecube, Albert; Megia, Ana; Vilarrasa, Nuria; Vendrell, Joan; Fernandez-Veledo, Sonia
Department: Medicina i Cirurgia; Ciències Mèdiques Bàsiques
URV's Author/s: Benaiges Moragrega, Ester / Ceperuelo Mallafré, Maria Victoria / Domínguez Porfirio, Brenno / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Martínez Salamero, Luis / Megía Colet, Ana / Vendrell Ortega, Juan José
Keywords: Weight loss; Validation study; Treatment outcome; Succinic acid; Sleeve gastrectomy; Roux-en-y gastric bypass; Risk factor; Remission induction; Remission; Randomized controlled trial; Prospective study; Prognosis; Preoperative period; Predictive value; Prediction; Obesity; Non insulin dependent diabetes mellitus; Middle aged; Male; Laparoscopy; Laparoscopic greater curvature plication; Humans; Human; Follow up; Female; Diabetes mellitus, type 2; Controlled study; Cohort studies; Cohort analysis; Clinical article; Biomarkers; Biological marker; Biochemical analysis; Bariatric surgery; Article; Anthropometric parameters; Aged; Adult
Abstract: © 2019 by the American Diabetes Association. OBJECTIVE To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery. RESEARCH DESIGN AND METHODS Forty-five obese patients with diabetes were randomly assigned to Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters were evaluated, and a complete biochemical analysis including circulating serum succinate concentrations was performed at baseline and 1 year after surgery. The results were externally validated in a second cohort including 88 obese patients with diabetes assigned to RYGB or SG based on clinical criteria. RESULTS Succinate baseline concentrations were an independent predictor of diabetes remission after bariatric surgery. Patients achieving remission after 1 year hadlower levels of baseline succinate (47.8 [37.6-64.6] mmol/L vs. 64.1 [52.5-82.9] μmol/L; P = 0.018). Moreover, succinate concentrations were significantly decreased 1 year after surgery (58.9 [46.4-82.4] μmol/L vs. 46.0 [35.8-65.3] mmol/L, P = 0.005). In multivariate analysis, the best logistic regression model showed that baseline succinate (odds ratio [OR] 11.3, P = 0.031) and the type of surgery (OR 26.4, P = 0.010) were independently associated with remission. The C-statistic for this model was 0.899 (95% CI 0.809-0.989) in the derivation cohort, which significantly improved the prediction of remission compared with current available scores, and 0.729 (95% CI 0.612-0.846) in the validation cohort. Interestingly, patients had a different response to the type of surgery according to baseline succinate, with significant differences in remission rates. CONCLUSIONS Circulating succinate is reduced after bariatric surgery. Baseline succinate levels have predictive value for diabetes remission independently of previously described presurgical factors and improve upon the current available scores to predict remission.
Thematic Areas: Saúde coletiva; Odontología; Nutrição; Medicina iii; Medicina ii; Medicina i; Internal medicine; Interdisciplinar; General medicine; Engenharias iv; Enfermagem; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Ciências biológicas ii; Ciências biológicas i; Biotecnología; Antropologia / arqueologia; Advanced and specialized nursing
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01495992
Author's mail: brenno.dominguez@urv.cat; victoria.ceperuelo@urv.cat; luis.martinez@urv.cat; ester.benaiges@estudiants.urv.cat; ester.benaiges@estudiants.urv.cat; sonia.fernandez@urv.cat; ana.megia@urv.cat; jvortega@iispv.cat
Record's date: 2025-03-03
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://care.diabetesjournals.org/content/42/10/1956
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Diabetes Care. 42 (10): 1956-1965
APA: Ceperuelo-Mallafre, Victoria; Llaurado, Gemma; Keiran, Noelia; Benaiges, Ester; Astiarraga, Brenno; Martinez, Laia; Pellitero, Silvia; Miguel Gonzalez (2019). Preoperative circulating succinate levels as a biomarker for diabetes remission after bariatric surgery. Diabetes Care, 42(10), 1956-1965. DOI: 10.2337/dc19-0114
Article's DOI: 10.2337/dc19-0114
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV