Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism

  • Identification data

    Identifier: imarina:5873597
    Authors:
    Miro-Blanch, JoanYanes, Oscar
    Abstract:
    Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.
  • Others:

    Author, as appears in the article.: Miro-Blanch, Joan; Yanes, Oscar
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Miró Blanch, Joan / Yanes Torrado, Óscar
    Keywords: Transplantation Transcription Posttranslational modifications Open chromatin Omics Microbiota Metabolomics Metabolism Impact Histones Epigenetics Donor feces Dna Diet-induced obesity Bacteria Acetylation
    Abstract: Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Molecular medicine Medicina veterinaria Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16648021
    Author's mail: oscar.yanes@urv.cat joan.miro@estudiants.urv.cat
    Author identifier: 0000-0003-3695-7157 0000-0003-3179-0554
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fgene.2019.00638/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Genetics. 10 (JUL): 638-638
    APA: Miro-Blanch, Joan; Yanes, Oscar (2019). Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Frontiers In Genetics, 10(JUL), 638-638. DOI: 10.3389/fgene.2019.00638
    Article's DOI: 10.3389/fgene.2019.00638
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Genetics,Genetics & Heredity,Genetics (Clinical),Molecular Medicine
    Transplantation
    Transcription
    Posttranslational modifications
    Open chromatin
    Omics
    Microbiota
    Metabolomics
    Metabolism
    Impact
    Histones
    Epigenetics
    Donor feces
    Dna
    Diet-induced obesity
    Bacteria
    Acetylation
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Odontología
    Molecular medicine
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
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