Articles producció científica> Ciències Mèdiques Bàsiques

Moderately elevated preconception fasting plasma total homocysteine is a risk factor for psychological problems in childhood

  • Identification data

    Identifier: imarina:5873710
    Authors:
    Roigé-Castellví J, Murphy M, Fernández-Ballart J, Canals J
    Abstract:
    We investigated the effect of maternal preconception fasting plasma total homocysteine (tHcy) on psychological problems in children aged 6 years from normal pregnancies.A longitudinal study was carried out from preconception, throughout each trimester of pregnancy, until 6 years of age in the offspring. Fasting blood samples at 2-10 weeks preconception and non-fasting samples at birth were collected. Parents completed the Child Behaviour Checklist (CBCL) and teachers the Inattention-Overactivity with Aggression (IOWA) scale for the 6-year-old children.Elevated tHcy during pregnancy has been associated with several adverse outcomes and with neurodevelopmental impairment in the offspring.ParticipantsThe initial sample consisted of 139 healthy non-pregnant women who were planning on becoming pregnant. Eighty-one mother-child dyads were followed from preconception until 6 years of age.After adjusting for covariables, multiple linear regression models showed that higher preconception tHcy was associated with higher scores in internalizing dimension (β=0·289; P=0.028), specifically in withdrawn behaviour (β=0·349; P=0·009), anxiety/depression (β=0·303; P=0·019) and social problems (β=0·372; P=0·009). Aggressive behaviour in the school setting was higher in children whose mothers had higher preconception tHcy (β=0·351; P=0·014).Moderately elevated preconception tHcy may increase the risk of psychological problems in offspring during childhood. These findings add to the evidence that maternal nutritional status, even before being pregnant, can affect later offspring health and may be important to consider when developing future public health policy.
  • Others:

    Author, as appears in the article.: Roigé-Castellví J, Murphy M, Fernández-Ballart J, Canals J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Canals Sans, Josefa / Fernández Ballart, Joan Domènech / Murphy, Michelle / Roigé Castellví, Joana
    Keywords: Association Autism spectrum disorders Behavioral-problems Behaviour problems Children Dementia Early-pregnancy Folic-acid supplementation Homocysteine Maternal folate status One-carbon metabolism Polymorphisms Preconception
    Abstract: We investigated the effect of maternal preconception fasting plasma total homocysteine (tHcy) on psychological problems in children aged 6 years from normal pregnancies.A longitudinal study was carried out from preconception, throughout each trimester of pregnancy, until 6 years of age in the offspring. Fasting blood samples at 2-10 weeks preconception and non-fasting samples at birth were collected. Parents completed the Child Behaviour Checklist (CBCL) and teachers the Inattention-Overactivity with Aggression (IOWA) scale for the 6-year-old children.Elevated tHcy during pregnancy has been associated with several adverse outcomes and with neurodevelopmental impairment in the offspring.ParticipantsThe initial sample consisted of 139 healthy non-pregnant women who were planning on becoming pregnant. Eighty-one mother-child dyads were followed from preconception until 6 years of age.After adjusting for covariables, multiple linear regression models showed that higher preconception tHcy was associated with higher scores in internalizing dimension (β=0·289; P=0.028), specifically in withdrawn behaviour (β=0·349; P=0·009), anxiety/depression (β=0·303; P=0·019) and social problems (β=0·372; P=0·009). Aggressive behaviour in the school setting was higher in children whose mothers had higher preconception tHcy (β=0·351; P=0·014).Moderately elevated preconception tHcy may increase the risk of psychological problems in offspring during childhood. These findings add to the evidence that maternal nutritional status, even before being pregnant, can affect later offspring health and may be important to consider when developing future public health policy.
    Thematic Areas: Antropologia / arqueologia Biodiversidade Biotecnología Ciência de alimentos Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias iii Engenharias iv Farmacia General medicine Interdisciplinar Matemática / probabilidade e estatística Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Nutrition & dietetics Nutrition and dietetics Odontología Planejamento urbano e regional / demografia Public health, environmental and occupational health Public, environmental & occupational health Saúde coletiva Serviço social Sociologia i política
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: michelle.murphy@urv.cat josefa.canals@urv.cat joana.roige@urv.cat
    ISSN: 13689800
    Author identifier: 0000-0002-6304-6204 0000-0002-6209-9558 0000-0002-9138-2360
    Record's date: 2023-02-22
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.cambridge.org/core/journals/public-health-nutrition/article/moderately-elevated-preconception-fasting-plasma-total-homocysteine-is-a-risk-factor-for-psychological-problems-in-childhood/759842D3FD877B080488B6D3FAC12ACE#
    Papper original source: Public Health Nutrition. 22 (9): 1615-1623
    APA: Roigé-Castellví J, Murphy M, Fernández-Ballart J, Canals J (2019). Moderately elevated preconception fasting plasma total homocysteine is a risk factor for psychological problems in childhood. Public Health Nutrition, 22(9), 1615-1623. DOI: 10.1017/S1368980018003610
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1017/S1368980018003610
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics,Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health
    Association
    Autism spectrum disorders
    Behavioral-problems
    Behaviour problems
    Children
    Dementia
    Early-pregnancy
    Folic-acid supplementation
    Homocysteine
    Maternal folate status
    One-carbon metabolism
    Polymorphisms
    Preconception
    Antropologia / arqueologia
    Biodiversidade
    Biotecnología
    Ciência de alimentos
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Educação física
    Enfermagem
    Engenharias iii
    Engenharias iv
    Farmacia
    General medicine
    Interdisciplinar
    Matemática / probabilidade e estatística
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Nutrição
    Nutrition & dietetics
    Nutrition and dietetics
    Odontología
    Planejamento urbano e regional / demografia
    Public health, environmental and occupational health
    Public, environmental & occupational health
    Saúde coletiva
    Serviço social
    Sociologia i política
    13689800
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