Author, as appears in the article.: Vázquez LI; Arija V; Aranda N; Aparicio E; Serrat N; Fargas F; Ruiz F; Pallejà M; Coronel P; Gimeno M; Basora J
Department: Ciències Mèdiques Bàsiques
e-ISSN: 2072-6643
URV's Author/s: Aparicio Llopis, Estefania / Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Iglesias Vazquez, Lucia
Keywords: hemoglobin hfe gene iron status iron stores iron supplementation pregnancy randomized controlled trial Anemia Consequences Hemoconcentration Hemoglobin Hfe gene Homeostasis Iron status Iron stores Iron supplementation Outcomes Pregnancy Prevalence Prophylaxis Questionnaire Randomized controlled trial Risk Serum ferritin Stores
Abstract: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110–130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 µg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.
Thematic Areas: Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias ii Engenharias iv Farmacia Food science Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Nutrition & dietetics Nutrition and dietetics Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lucia.iglesias@urv.cat josep.basora@urv.cat victoria.arija@urv.cat lucia.iglesias@urv.cat nuria.aranda@urv.cat josep.basora@urv.cat estefania.aparicio@urv.cat
ISSN: 20726643
Author identifier: 0000-0001-7131-4144 0000-0002-1758-0975 0000-0001-7131-4144 0000-0001-9708-747X 0000-0003-0542-0015
Record's date: 2023-02-18
Journal volume: 11
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/11/10/2418
Papper original source: Nutrients. 11 (10):
APA: Vázquez LI; Arija V; Aranda N; Aparicio E; Serrat N; Fargas F; Ruiz F; Pallejà M; Coronel P; Gimeno M; Basora J (2019). The effectiveness of different doses of iron supplementation and the prenatal determinants of maternal iron status in pregnant spanish women: ECLIPSES study. Nutrients, 11(10), -. DOI: 10.3390/nu11102418
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/nu11102418
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications