Author, as appears in the article.: Guardia-Escote L; Basaure P; Biosca-Brull J; Cabré M; Blanco J; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M
Department: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia
URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Keywords: Window Targeted replacement Short-chain fatty acids Metabolism Intestinal microbiota Impact Health Gut microbiota Chlorpyrifos Butyrate Body-weight Apolipoprotein-e gene Apoe Akkermansia-muciniphila Akkermansia muciniphila gut microbiota chlorpyrifos apoe akkermansia muciniphila
Abstract: © 2019 Elsevier Ltd The gut microbiota comprises a large number of microorganisms, whose composition can be modified by genetic and environmental factors. The host's genetic background, including the different isoforms of the apolipoprotein E (APOE) gene, can exert an influence over microbiota composition. Exposure to the widely-used pesticide chlorpyrifos (CPF), can lead to dysbiosis and alter the levels of metabolites produced by the microbiota, such as short-chain fatty acids (SCFAs). This study was aimed at assessing the contribution of the APOE genotype and early exposure to CPF on gut microbiota and SCFA in brain. For it, C57BL/6, apoE3-and apoE4-TR mice were orally exposed to CPF from postnatal day (PND) 10 to PND 15. Microbiota in the gut and SCFA in the brain were assessed at PND 15 after CPF exposure. Differences between genotypes at different taxonomic levels were found, A. muciniphila presented greater abundance in APOE4 genotype, but was reduced by CPF exposure. APOE and CPF influenced cerebral SCFAs, with APOE3 genotype showing the highest levels of acetic, propionic and butyric acids and CPF exposure inducing the highest levels of isovaleric and 4-methylvaleric acids. These results provide further knowledge about gut microbiota and cerebral SCFAs composition at early ages and their modulation by APOE and postnatal CPF exposure.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Author's mail: jordi.blanco@urv.cat mariateresa.colomina@urv.cat joseluis.domingo@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat maria.cabre@urv.cat
Author identifier: 0000-0001-8016-0984 0000-0002-5619-4874 0000-0001-6647-9470 0000-0003-4124-8603
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691519306623?via%3Dihub
Papper original source: Food And Chemical Toxicology. 135 (110872): 110872-
APA: Guardia-Escote L; Basaure P; Biosca-Brull J; Cabré M; Blanco J; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M (2020). APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice. Food And Chemical Toxicology, 135(110872), 110872-. DOI: 10.1016/j.fct.2019.110872
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.fct.2019.110872
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV