Author, as appears in the article.: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Marta; Torres, Josep L.;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Miralles Pérez, Bernat / Romeu Ferran, Marta
Keywords: Resistance Obesity Metabolism Metabolic syndrome Leptin Fructose Food Diet Diabetes D-fagomine Blood pressure fructose diabetes d-fagomine blood pressure
Abstract: Scope This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F-2t isoprostanes (F-2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F-2-IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention. Conclusion d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Author's mail: bmirallesperez@gmail.com marta.romeu@urv.cat
Author identifier: 0000-0003-1294-7069 0000-0002-2131-1858
Record's date: 2024-10-19
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201900564
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 64 (1): e1900564-
APA: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Ma (2020). The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. Molecular Nutrition & Food Research, 64(1), e1900564-. DOI: 10.1002/mnfr.201900564
Article's DOI: 10.1002/mnfr.201900564
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV