Author, as appears in the article.: Coll-Padros, Nina; Leon, Maria; Valech, Natalia; Ros, Emilio; Vidal, Josep; Estruch, Ramon; Fito, Montserrat; Salas-Salvado, Jordi; Corella, Dolores; Luis Molinuevo, Jose; Rami, Lorena;

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Risk Prevalence Predimed-plus study Physical activity Obesity Metabolic syndrome Individuals Exercise Dementia Decline Cognitive function Brain health Aging predimed-plus study obesity metabolic syndrome cognitive function aging

Abstract: Background There is epidemiological evidence of an association between the metabolic syndrome (MetS), a cluster of cardiovascular risk factors related to central adiposity and insulin resistance, and cognitive impairment and dementia. On the other hand, there is evidence for a beneficial effect of physical activity on cognitive outcomes in older adult populations. In a cross-sectional study, we evaluated the relationship between aerobic physical activity and cognition in a cohort of overweight/obese older adults with MetS at risk for dementia. Cognitive function was assessed in a subsample of 82 subjects (men 55-75 y; women 60-75 y), with MetS and a BMI >= 27 to < 40 kg/m(2) enrolled in the PREDIMED-PLUS study, a trial of diet and exercise in individuals with MetS with outcomes of cardiovascular prevention. Domain Z scores were calculated for the different cognitive domains. Aerobic physical activity was determined with the Rapid Assessment of Physical Activity questionnaire. Results Adjusted covariance analyses revealed that, compared to sedentary participants, those physically active obtained higher scores in mean global cognitive scores, with mean adjusted difference 0.254 (95% CI 0.032 to 0.477, p = 0.026) and frontal composites, with mean adjusted difference 0.375 (95% CI 0.110 to 0.639, p = 0.006). Conclusions Our findings indicate that aerobic physical activity is associated with better global cognition and frontal function in overweight/obese older individuals with MetS, suggesting that physical activity could be a therapeutic strategy to reduce the risk of developing cognitive impairment or dementia in this population.

Thematic Areas: Interdisciplinar Geriatrics and gerontology Geriatrics & gerontology Educação física Ciências biológicas ii Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 18137253

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://eurapa.biomedcentral.com/articles/10.1186/s11556-019-0229-y

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: European Review Of Aging And Physical Activity. 16 (1): 23-

APA: Coll-Padros, Nina; Leon, Maria; Valech, Natalia; Ros, Emilio; Vidal, Josep; Estruch, Ramon; Fito, Montserrat; Salas-Salvado, Jordi; Corella, Dolores; (2019). Physical activity is associated with better global cognition and frontal function in overweight/obese older adults with metabolic syndrome. European Review Of Aging And Physical Activity, 16(1), 23-. DOI: 10.1186/s11556-019-0229-y

Article's DOI: 10.1186/s11556-019-0229-y

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications