Articles producció científica> Bioquímica i Biotecnologia

Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-Plus trial: Role of body mass index and sex

  • Identification data

    Identifier: imarina:6012035
    Authors:
    Tresserra-Rimbau ACastro-Barquero SVitelli-Storelli FBecerra-Tomas NVázquez-Ruiz ZDíaz-López ACorella DCastañer ORomaguera DVioque JAlonso-Gómez ÁMWärnberg JMartínez JASerra-Majem LEstruch RTinahones FJLapetra JPintó XTur JALópez-Miranda JGarcía-Molina LDelgado-Rodríguez MMatía-Martín PDaimiel LRubín-García MVidal JGaldon ARos EBasterra-Gortari FJBabio NSorlí JVHernáez ÁKonieczna JNotario-Barandiaran LTojal-Sierra LPérez-López JAbete IÁlvarez-Pérez JFernández-García JCSantos-Lozano JMGalera-Cusí AJulibert ARuiz-Canela MMartínez-Lacruz RPérez-Vega KAGalmes-Panades AMPastor-Polo CMoreno-Rodríguez AGea AFitó MLamuela-Raventós RMSalas-Salvadó J
    Abstract:
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
  • Others:

    Author, as appears in the article.: Tresserra-Rimbau A; Castro-Barquero S; Vitelli-Storelli F; Becerra-Tomas N; Vázquez-Ruiz Z; Díaz-López A; Corella D; Castañer O; Romaguera D; Vioque J; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; García-Molina L; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Rubín-García M; Vidal J; Galdon A; Ros E; Basterra-Gortari FJ; Babio N; Sorlí JV; Hernáez Á; Konieczna J; Notario-Barandiaran L; Tojal-Sierra L; Pérez-López J; Abete I; Álvarez-Pérez J; Fernández-García JC; Santos-Lozano JM; Galera-Cusí A; Julibert A; Ruiz-Canela M; Martínez-Lacruz R; Pérez-Vega KA; Galmes-Panades AM; Pastor-Polo C; Moreno-Rodríguez A; Gea A; Fitó M; Lamuela-Raventós RM; Salas-Salvadó J
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2076-3921
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Díaz López, Andres / Salas Salvadó, Jorge
    Keywords: Catechins Diet Flavonoids Hydroxybenzoic acids Hydroxycinnamic acids Lignans Obesity Phenolic acids Proanthocyanidins
    Abstract: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
    Thematic Areas: Biochemistry Biochemistry & molecular biology Biodiversidade Biotecnología Cell biology Chemistry, medicinal Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Clinical biochemistry Engenharias ii Farmacia Food science Food science & technology Interdisciplinar Medicina i Medicina ii Molecular biology Physiology Química
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat
    ISSN: 20763921
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277 0000-0002-7500-5629 0000-0002-4429-6507
    Record's date: 2023-07-31
    Journal volume: 8
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3921/8/11/537
    Papper original source: Antioxidants. 8 (11): 537-
    APA: Tresserra-Rimbau A; Castro-Barquero S; Vitelli-Storelli F; Becerra-Tomas N; Vázquez-Ruiz Z; Díaz-López A; Corella D; Castañer O; Romaguera D; Vioque J (2019). Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-Plus trial: Role of body mass index and sex. Antioxidants, 8(11), 537-. DOI: 10.3390/antiox8110537
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3390/antiox8110537
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Catechins
    Diet
    Flavonoids
    Hydroxybenzoic acids
    Hydroxycinnamic acids
    Lignans
    Obesity
    Phenolic acids
    Proanthocyanidins
    Biochemistry
    Biochemistry & molecular biology
    Biodiversidade
    Biotecnología
    Cell biology
    Chemistry, medicinal
    Ciência de alimentos
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Clinical biochemistry
    Engenharias ii
    Farmacia
    Food science
    Food science & technology
    Interdisciplinar
    Medicina i
    Medicina ii
    Molecular biology
    Physiology
    Química
    20763921
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