Author, as appears in the article.: Hereu, Merce; Ramos-Romero, Sara; Marin-Valls, Roser; Amezqueta, Susana; Miralles-Perez, Bernat; Romeu, Marta; Mendez, Lucia; Medina, Isabel; Lluis Torres, Josep
Department: Ciències Mèdiques Bàsiques
e-ISSN: 2072-6643
URV's Author/s: Miralles Pérez, Bernat / Romeu Ferran, Marta
Keywords: Ω-3 pufas; Wistar; Weight; Seafood; Rats, sprague-dawley; Rats; Prevotella; Polyunsaturated fatty-acids; Omega-3 pufas; Model; Microbiota; Metabolites; Male; Lactobacillus; Insulin-resistance; Impact; Iminosugar; Iminocyclitol; Imino pyranoses; Gut microbiota; Gastrointestinal microbiome; Fatty acids, omega-3; Fagopyrum; Fagomine; Dietary supplements; Diet; D-fagomine; Body weight; Bacteroides; Animals; Administration, oral; Acetate; ?-3 pufas; weight; prevotella; iminosugar; iminocyclitol; gut microbiota; d-fagomine; bacteroides
Abstract: Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of D-fagomine and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA 1:1) on putatively beneficial gut bacterial strains. Male Sprague-Dawley rats were supplemented with D-fagomine, omega-3 PUFAs, or both, for 23 weeks. Bacterial subgroups were evaluated in fecal DNA by quantitative real-time polymerase chain reaction (qRT-PCR) and short-chain fatty acids were determined by gas chromatography. We found that the populations of the genus Prevotella remained stable over time in animals supplemented with D-fagomine, independently of omega-3 PUFA supplementation. Animals in these groups gained less weight than controls and rats given only omega-3 PUFAs. D-Fagomine supplementation together with omega-3 PUFAs maintained the relative populations of Bacteroides. omega-3 PUFAs alone or combined with D-fagomine reduced the amount of acetic acid and total short-chain fatty acids in feces. The plasma levels of pro-inflammatory arachidonic acid derived metabolites, triglycerides and cholesterol were lower in both groups supplemented with omega-3 PUFAs. The D-fagomine and omega-3 PUFAs combination provided the functional benefits of each supplement. Notably, it helped stabilize populations of Prevotella in the rat intestinal tract while reducing weight gain and providing the anti-inflammatory and cardiovascular benefits of omega-3 PUFAs.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: bmirallesperez@gmail.com; marta.romeu@urv.cat
Record's date: 2025-02-19
Journal volume: 11
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/11/11/2606
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 11 (11): 2606-
APA: Hereu, Merce; Ramos-Romero, Sara; Marin-Valls, Roser; Amezqueta, Susana; Miralles-Perez, Bernat; Romeu, Marta; Mendez, Lucia; Medina, Isabel; Lluis To (2019). Combined Buckwheat D-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats. Nutrients, 11(11), 2606-. DOI: 10.3390/nu11112606
Article's DOI: 10.3390/nu11112606
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV