Author, as appears in the article.: Lanuza, Maria A; Just-Borras, Laia; Hurtado, Erica; Cilleros-Mane, Victor; Tomas, Marta; Garcia, Neus; Tomas, Josep
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Hurtado Caballero, Erica / Just Borràs, Laia / Lanuza Escolano, María Angel / Tomás Ferré, José Maria / Tomas Marginet, Marta / Tomàs Porres, Josep
Keywords: Tropomyosin-related kinase-b, human Trkb Transmitter release Transgenic mouse model Skeletal-muscle Signal transduction Receptor, trkb Protein-kinase Protein kinase c Presynaptic muscarinic autoreceptors Pkc Nmj Neurotrophic factor Neuromuscular junction Neuromuscular Muscle, skeletal Motor-neuron Motor neurons Membrane glycoproteins Kinase In-vivo Humans Gene expression Exercise Brain-derived neurotrophic factor Bdnf protein, human Bdnf Animals Amyotrophic lateral sclerosis Als Adult-rat Acetylcholine-release 10.3390/cells8121578 trkb pkc nmj kinase exercise bdnf als
Abstract: Brain-derived neurotrophic factor (BDNF) promotes neuron survival in adulthood in the central nervous system. In the peripheral nervous system, BDNF is a contraction-inducible protein that, through its binding to tropomyosin-related kinase B receptor (TrkB), contributes to the retrograde neuroprotective control done by muscles, which is necessary for motor neuron function. BDNF/TrkB triggers downstream presynaptic pathways, involving protein kinase C, essential for synaptic function and maintenance. Undeniably, this reciprocally regulated system exemplifies the tight communication between nerve terminals and myocytes to promote synaptic function and reveals a new view about the complementary and essential role of pre and postsynaptic interplay in keeping the synapse healthy and strong. This signaling at the neuromuscular junction (NMJ) could establish new intervention targets across neuromuscular diseases characterized by deficits in presynaptic activity and muscle contractility and by the interruption of the connection between nervous and muscular tissues, such as amyotrophic lateral sclerosis (ALS). Indeed, exercise and other therapies that modulate kinases are effective at delaying ALS progression, preserving NMJs and maintaining motor function to increase the life quality of patients. Altogether, we review synaptic activity modulation of the BDNF/TrkB/PKC signaling to sustain NMJ function, its and other kinases' disturbances in ALS and physical and molecular mechanisms to delay disease progression.
Thematic Areas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20734409
Author's mail: josep.tomas@urv.cat laia.just@urv.cat marta.tomas@urv.cat erica.hurtado@urv.cat josep.tomas@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat
Author identifier: 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2073-4409/8/12/1578
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cells. 8 (12): E1578-
APA: Lanuza, Maria A; Just-Borras, Laia; Hurtado, Erica; Cilleros-Mane, Victor; Tomas, Marta; Garcia, Neus; Tomas, Josep (2019). The Impact of Kinases in Amyotrophic Lateral Sclerosis at the Neuromuscular Synapse: Insights into BDNF/TrkB and PKC Signaling. Cells, 8(12), E1578-. DOI: 10.3390/cells8121578
Article's DOI: 10.3390/cells8121578
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV