Articles producció científica> Bioquímica i Biotecnologia

Dysfunctional HDLs are Associated with a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested-Case Control Study

  • Identification data

    Identifier: imarina:6040372
    Authors:
    Soria-Florido, Maria TrinidadCastaner, OlgaLassale, CamilleEstruch, RamonSalas-Salvado, JordiMartinez-Gonzalez, Miguel AngelCorella, DoloresRos, EmilioAros, FernandoElosua, RobertoLapetra, JoseFiol, MiquelAlonso-Gomez, AngelGomez-Gracia, EnriqueSerra-Majem, LluisPinto, XavierBullo, MonicaRuiz-Canela, MiguelSorli, Jose VHernaez, AlvaroFito, Montserrat
    Abstract:
    Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that HDL atheroprotective role lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been comprehensively investigated. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial where participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched (1:2) to controls by sex, age, intervention group, body mass index, and follow-up time. We investigated its two individual manifestations (myocardial infarction, unstable angina) as secondary outcomes. We measured the following functional characteristics: HDL cholesterol concentration (in plasma); cholesterol efflux capacity; antioxidant ability measured by the HDL oxidative-inflammatory index; phospholipase A2 activity; and sphingosine-1-phosphate, apolipoproteins A-I and A-IV, serum amyloid A, and complement 3 protein (in apolipoprotein B-depleted plasma). We used conditional logistic regression models adjusted for HDL cholesterol levels and cardiovascular risk factors to estimate odds ratios (ORs) between one standard deviation increments in HDL functional characteristics and clinical outcomes. Results: Low values of cholesterol efflux capacity (OR1SD: 0.58, 95% CI: 0.40-0.83), and levels of sphingosine-1-phosphate (OR1SD: 0.70, 95% CI: 0.52-0.92), and apolipoprotein A-I (OR1SD: 0.58, 95% CI: 0.42-0.79) were associated with higher odds of acute coronary syndrome. Higher HDL oxidative inflamma
  • Others:

    Author, as appears in the article.: Soria-Florido, Maria Trinidad; Castaner, Olga; Lassale, Camille; Estruch, Ramon; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel Angel; Corella, Dolores; Ros, Emilio; Aros, Fernando; Elosua, Roberto; Lapetra, Jose; Fiol, Miquel; Alonso-Gomez, Angel; Gomez-Gracia, Enrique; Serra-Majem, Lluis; Pinto, Xavier; Bullo, Monica; Ruiz-Canela, Miguel; Sorli, Jose V; Hernaez, Alvaro; Fito, Montserrat
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Keywords: Sphingosine-1-phosphate Rupture Plaque High-density lipoproteins Heart-disease Hdl functions Hdl cholesterol Events Cholesterol efflux capacity Artery-disease Acute coronary syndrome
    Abstract: Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that HDL atheroprotective role lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been comprehensively investigated. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial where participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched (1:2) to controls by sex, age, intervention group, body mass index, and follow-up time. We investigated its two individual manifestations (myocardial infarction, unstable angina) as secondary outcomes. We measured the following functional characteristics: HDL cholesterol concentration (in plasma); cholesterol efflux capacity; antioxidant ability measured by the HDL oxidative-inflammatory index; phospholipase A2 activity; and sphingosine-1-phosphate, apolipoproteins A-I and A-IV, serum amyloid A, and complement 3 protein (in apolipoprotein B-depleted plasma). We used conditional logistic regression models adjusted for HDL cholesterol levels and cardiovascular risk factors to estimate odds ratios (ORs) between one standard deviation increments in HDL functional characteristics and clinical outcomes. Results: Low values of cholesterol efflux capacity (OR1SD: 0.58, 95% CI: 0.40-0.83), and levels of sphingosine-1-phosphate (OR1SD: 0.70, 95% CI: 0.52-0.92), and apolipoprotein A-I (OR1SD: 0.58, 95% CI: 0.42-0.79) were associated with higher odds of acute coronary syndrome. Higher HDL oxidative inflammatory index values were marginally linked to acute coronary syndrome risk (OR1SD: 1.27, 95% CI: 0.99-1.63). Low values of cholesterol efflux capacity (OR1SD: 0.33, 95% CI: 0.18-0.61), sphingosine-1-phosphate (OR1SD: 0.60, 95% CI: 0.40-0.89) and apolipoprotein A-I (OR1SD: 0.59, 95% CI: 0.37-0.93) were particularly linked to myocardial infarction, whereas high HDL oxidative-inflammatory index values (OR1SD: 1.53, 95% CI: 1.01-2.33) and low apolipoprotein A-I levels (OR1SD: 0.52, 95% CI: 0.31-0.88) were associated with unstable angina. Conclusions: Low cholesterol efflux capacity values, pro-oxidant/pro-inflammatory HDL particles, and low HDL levels of sphingosine-1-phosphate and apolipoprotein A-I were associated with increased odds of acute coronary syndrome and its manifestations in high cardiovascular risk subjects. Clinical Trial Registration: URL: http://www.controlled-trials.com Unique identifier: ISRCTN35739639.
    Thematic Areas: Saúde coletiva Physiology (medical) Peripheral vascular disease Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00097322
    Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041658
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Circulation. 141 (6): 444-453
    APA: Soria-Florido, Maria Trinidad; Castaner, Olga; Lassale, Camille; Estruch, Ramon; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel Angel; Corella, Dolor (2020). Dysfunctional HDLs are Associated with a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested-Case Control Study. Circulation, 141(6), 444-453. DOI: 10.1161/circulationaha.119.041658
    Article's DOI: 10.1161/circulationaha.119.041658
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Hematology,Peripheral Vascular Disease,Physiology (Medical)
    Sphingosine-1-phosphate
    Rupture
    Plaque
    High-density lipoproteins
    Heart-disease
    Hdl functions
    Hdl cholesterol
    Events
    Cholesterol efflux capacity
    Artery-disease
    Acute coronary syndrome
    Saúde coletiva
    Physiology (medical)
    Peripheral vascular disease
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Hematology
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência da computação
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
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