Author, as appears in the article.: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
Department: Medicina i Cirurgia
URV's Author/s: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria
Project code: 713679
Keywords: Urine Raspberry Polyphenols Plasma Phenolic-compounds Pharmacokinetics Metabolites Fruit Diet Cyanidin-3-glucoside Cyanidin 3-glucoside Blackberry anthocyanins Biomarker Bioavailability Berry Anthocyanins plasma cyanidin-3-glucoside biomarker berry anthocyanins
Abstract: Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far.The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine.PubMed and Cochrane databases were searched from January 2008 to January 2019.Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded.Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve.Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P?=?0.210) in plasma, which is acceptable, and 61.7% (P?=?0.402) in urine.Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans.CRD42018096796.© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.
Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00296643
Author's mail: elisabet.llaurado@urv.cat ursula.catalan@urv.cat rosa.sola@urv.cat
Author identifier: 0000-0002-7439-9531 0000-0001-8884-9823 0000-0002-8359-235X
Record's date: 2023-07-31
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://academic.oup.com/nutritionreviews/article/78/7/597/5681776
Funding program: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
Papper original source: Nutrition Reviews. 78 (7): 597-610
APA: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R. (2020). Cyanidin-3-glucoside as a possible biomarker for anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials.. Nutrition Reviews, 78(7), 597-610. DOI: 10.1093/nutrit/nuz083
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Acronym: MFP
Article's DOI: 10.1093/nutrit/nuz083
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Funding program action: Martí i Franquès COFUND Doctoral Programme
Publication Type: Journal Publications