Articles producció científica> Bioquímica i Biotecnologia

Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling

  • Identification data

    Identifier: imarina:6051415
    Authors:
    Torres-Fuentes, CGolubeva, AVZhdanov, AVWallace, SArboleya, SPapkovsky, DBEl Aidy, SRoss, PRoy, BLStanton, CDinan, TGCryan, JFSchellekens, H
    Abstract:
    The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] is a GPCR expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. To date, few studies have investigated the potential of the gastrointestinal microbiota and its metabolites to modulate GPCR signaling. Here we investigate the ability of short-chain fatty acids (SCFAs), lactate, and different bacterial strains, including Bifidobacterium and Lactobacillus genera, to modulate GHSR-1a signaling. We identify, for what is to our knowledge the first time, a potent effect of microbiota-derived metabolites on GHSR-1a signaling with potential significant consequences for host metabolism and physiology. We show that SCFAs, lactate, and bacterial supernatants are able to attenuate ghrelin-mediated signaling through the GHSR-1a. We suggest a novel route of communication between the gut microbiota and the host via modulation of GHSR-1a receptor signaling. Together, this highlights the emerging therapeutic potential in the exploration of the microbiota metabolome in the specific targeting of key GPCRs, with pleiotropic actions that span both the CNS and periphery.
  • Others:

    Author, as appears in the article.: Torres-Fuentes, C; Golubeva, AV; Zhdanov, AV; Wallace, S; Arboleya, S; Papkovsky, DB; El Aidy, S; Ross, P; Roy, BL; Stanton, C; Dinan, TG; Cryan, JF; Schellekens, H
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Torres Fuentes, Cristina
    Keywords: Scfa Probiotics Motility Mechanisms Lactate Increase Hormone secretagogue receptor High constitutive activity Gut-brain axis Gut bacteria Ghsr-1a Expression Diet Cells Acute lung injury scfa lactate gut bacteria ghsr-1a
    Abstract: The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] is a GPCR expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. To date, few studies have investigated the potential of the gastrointestinal microbiota and its metabolites to modulate GPCR signaling. Here we investigate the ability of short-chain fatty acids (SCFAs), lactate, and different bacterial strains, including Bifidobacterium and Lactobacillus genera, to modulate GHSR-1a signaling. We identify, for what is to our knowledge the first time, a potent effect of microbiota-derived metabolites on GHSR-1a signaling with potential significant consequences for host metabolism and physiology. We show that SCFAs, lactate, and bacterial supernatants are able to attenuate ghrelin-mediated signaling through the GHSR-1a. We suggest a novel route of communication between the gut microbiota and the host via modulation of GHSR-1a receptor signaling. Together, this highlights the emerging therapeutic potential in the exploration of the microbiota metabolome in the specific targeting of key GPCRs, with pleiotropic actions that span both the CNS and periphery.
    Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Cell biology Biotecnología Biotechnology Biology Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 08926638
    Author's mail: cristina.torres@urv.cat
    Author identifier: 0000-0002-2917-6910
    Record's date: 2024-02-11
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.201901433Rhttps://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.201901433R
    Papper original source: Faseb Journal. 33 (12): 13546-13559
    APA: Torres-Fuentes, C; Golubeva, AV; Zhdanov, AV; Wallace, S; Arboleya, S; Papkovsky, DB; El Aidy, S; Ross, P; Roy, BL; Stanton, C; Dinan, TG; Cryan, JF; (2019). Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. Faseb Journal, 33(12), 13546-13559. DOI: 10.1096/fj.201901433R
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1096/fj.201901433R
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Biology,Biotechnology,Cell Biology,Genetics,Medicine (Miscellaneous),Molecular Biology
    Scfa
    Probiotics
    Motility
    Mechanisms
    Lactate
    Increase
    Hormone secretagogue receptor
    High constitutive activity
    Gut-brain axis
    Gut bacteria
    Ghsr-1a
    Expression
    Diet
    Cells
    Acute lung injury
    scfa
    lactate
    gut bacteria
    ghsr-1a
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics
    General medicine
    Farmacia
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Cell biology
    Biotecnología
    Biotechnology
    Biology
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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