Articles producció científica> Enginyeria Química

Organophosphate metabolite concentrations in maternal urine during pregnancy

  • Identification data

    Identifier: imarina:6063463
    Authors:
    Bravo NPeralta SGrimalt JMartínez MRovira JSchuhmacher M
    Abstract:
    © 2019 Elsevier Inc. The burden of organophosphate (OP) pesticides in pregnant women from Tarragona (n = 157), a Mediterranean area of intense agricultural activity, has been assessed from the study of hydroxylated organic metabolites in urine samples in the three trimesters of pregnancy. 2-Diethylamino-6-methylpyrimidin-4-ol (DEAMPY), a metabolite of pirimiphos, was the compound found in higher concentration, medians 0.66–2.8 μg/g creatinine. 4-Nitrophenol (PNP), a metabolite of parathion, medians 0.24–0.41 μg/g creatinine, was the second most abundant compound. 2-Isopropyl-6-methyl-4-pyrimidol (IMPY), a metabolite of diazinon, was also present but in lower concentrations. Except for DEAMPY, the concentrations found in this cohort were lower than those reported in studies from other countries. Intraclass correlation coefficients (ICCs) were calculated for the compounds found in more than the 35% of the samples, the reliability between trimesters was poor (<0.40) to fair (0.40–0.60). Statistically significant differences were observed for the creatinine adjusted concentrations of the most abundant OP metabolites in these trimesters when examined with the Wilcoxon signed rank test for paired data. In general, no association was found between urinary OP metabolites and most demographic and lifestyle predictors. However, a positive significant association was observed for women with vegetarian diet and for women of higher economic status and eventual consumption of organic food which showed higher PNP concentrations. These results suggest that higher fruit and vegetable consumption may involve higher OP pesticide ingestion but the overall association was weak.
  • Others:

    Author, as appears in the article.: Bravo N; Peralta S; Grimalt J; Martínez M; Rovira J; Schuhmacher M
    Department: Ciències Mèdiques Bàsiques Enginyeria Química
    URV's Author/s: Martínez Rodríguez, María Ángeles / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta
    Keywords: Reproducibility of results Pyrethroids Pregnant women Pregnancy Pesticides Organophosphorus pesticides Organophosphorus compounds Organophosphates Maternal exposure Humans Human biomonitoring Female Environmental exposure Agriculture pregnant women organophosphorus pesticides human biomonitoring agriculture
    Abstract: © 2019 Elsevier Inc. The burden of organophosphate (OP) pesticides in pregnant women from Tarragona (n = 157), a Mediterranean area of intense agricultural activity, has been assessed from the study of hydroxylated organic metabolites in urine samples in the three trimesters of pregnancy. 2-Diethylamino-6-methylpyrimidin-4-ol (DEAMPY), a metabolite of pirimiphos, was the compound found in higher concentration, medians 0.66–2.8 μg/g creatinine. 4-Nitrophenol (PNP), a metabolite of parathion, medians 0.24–0.41 μg/g creatinine, was the second most abundant compound. 2-Isopropyl-6-methyl-4-pyrimidol (IMPY), a metabolite of diazinon, was also present but in lower concentrations. Except for DEAMPY, the concentrations found in this cohort were lower than those reported in studies from other countries. Intraclass correlation coefficients (ICCs) were calculated for the compounds found in more than the 35% of the samples, the reliability between trimesters was poor (<0.40) to fair (0.40–0.60). Statistically significant differences were observed for the creatinine adjusted concentrations of the most abundant OP metabolites in these trimesters when examined with the Wilcoxon signed rank test for paired data. In general, no association was found between urinary OP metabolites and most demographic and lifestyle predictors. However, a positive significant association was observed for women with vegetarian diet and for women of higher economic status and eventual consumption of organic food which showed higher PNP concentrations. These results suggest that higher fruit and vegetable consumption may involve higher OP pesticide ingestion but the overall association was weak.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0013-9351
    Author's mail: mangeles.martinez@urv.cat joaquim.rovira@urv.cat marta.schuhmacher@urv.cat
    Author identifier: 0000-0001-8595-3772 0000-0003-4399-6138 0000-0003-4381-2490
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S001393511930800X?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Environmental Research. 182 (109003): 109003-
    APA: Bravo N; Peralta S; Grimalt J; Martínez M; Rovira J; Schuhmacher M (2020). Organophosphate metabolite concentrations in maternal urine during pregnancy. Environmental Research, 182(109003), 109003-. DOI: 10.1016/j.envres.2019.109003
    Article's DOI: 10.1016/j.envres.2019.109003
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Reproducibility of results
    Pyrethroids
    Pregnant women
    Pregnancy
    Pesticides
    Organophosphorus pesticides
    Organophosphorus compounds
    Organophosphates
    Maternal exposure
    Humans
    Human biomonitoring
    Female
    Environmental exposure
    Agriculture
    pregnant women
    organophosphorus pesticides
    human biomonitoring
    agriculture
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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