Author, as appears in the article.: Cardenas Fuentes, Gabriela; Castaner, Olga; Warnberg, Julia; Subirana, Isaac; Buil-Cosiales, Pilar; Salas-Salvado, Jordi; Corella, Dolores; Serra-Majem, Lluis; Romaguera, Dora; Estruch, Ramon; Alfredo Martinez, J; Pinto, Xavier; Vazquez, Clotilde; Vidal, Josep; Tur, Josep A; Aros, Fernando; Bullo, Monica; Fito, Montserrat; Schroder, Helmut
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Time Sedentary behavior Risk Prospective study Plasma Moderate-to-vigorous physical activity Men Markers Light physical activity Inflammatory score Inflammation Exercise Diet Chronic diseases C-reactive protein moderate-to-vigorous physical activity light physical activity inflammatory score inflammation
Abstract: © 2020 Background: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese. Methods: This prospective study included 489 men and women, aged 55–75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up. Results: Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006). Conclusions: Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies. Clinical trial registry: Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02615614
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30038-8/abstract
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Nutrition. 39 (10): 3092-3098
APA: Cardenas Fuentes, Gabriela; Castaner, Olga; Warnberg, Julia; Subirana, Isaac; Buil-Cosiales, Pilar; Salas-Salvado, Jordi; Corella, Dolores; Serra-Maje (2020). Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome. Clinical Nutrition, 39(10), 3092-3098. DOI: 10.1016/j.clnu.2020.01.015
Article's DOI: 10.1016/j.clnu.2020.01.015
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV