Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED-Plus Study

Identifier:  imarina:6124593

Handle: https://hdl.handle.net/20.500.11797/imarina6124593

Authors:  Fernandez-Garcia, Jose Carlos; Munoz-Garach, Araceli; Martinez-Gonzalez, Miguel angel; Salas-Salvado, Jordi; Corella, Dolores; Hernaez, Alvaro; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, J Alfredo; Serra-Majem, Luis; Estruch, Ramon; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Garcia-Rios, Antonio; Garcia Molina, Laura; Gaforio, Jose Juan; Matia-Martin, Pilar; Daimiel, Lidia; Martin Sanchez, Vicente; Vidal, Josep; Prieto, Lucia; Ros, Emilio; Goni, Nuria; Babio, Nancy; Ortega-Azorin, Carolina; Castaner, Olga; Konieczna, Jadwiga; Notario Barandiaran, Leyre; Vaquero-Luna, Jessica; Benavente-Marin, Juan Carlos; Zulet, M Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Gomez Huelgas, Ricardo; Miro-Moriano, Leticia; Gimenez-Gracia, Mariano; Julibert, Alicia; Razquin, Cristina; Basora, Josep; Portoles, Olga; Goday, Albert; Galmes-Panades, Aina M; Lopez-Garcia, Carmen M; Moreno-Rodriguez, Anai; Toledo, Estefania; Diaz-Lopez, Andres; Fito, Montserrat; Tinahones, Francisco J; Bernal-Lopez, M Rosa

Abstract:
Objective The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined. Methods A total of 6,874 individuals aged 55 to 75 with BMI >= 27 and < 40 kg/m(2) were included and classified by presence (HTGW(+)) or absence (HTGW(-)) of HTGW (waist circumference: men >= 102 cm, women >= 88 cm; fasting plasma triglycerides >= 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed. Results A total of 38.2% of the sample met HTGW(+) criteria. HTGW(+) individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low-density lipoprotein cholesterol levels; had lower high-density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW(-) patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW(+). Conclusions HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW(-) individuals were more physically active with greater total physical activity, and fewer had hypertension.