Author, as appears in the article.: Amigo, Nuria; Akinkuolie, Akintunde O; Chiuve, Stephanie E; Correig, Xavier; Cook, Nancy R; Mora, Samia
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Correig Blanchar, Francesc Xavier
Keywords: Triglycerides Surveys and questionnaires Sex factors Reference values N‐3 Nuclear magnetic resonance lipoprotein subfractions N?3 Magnetic resonance spectroscopy Lipoproteins Humans Fishes Fish Female Feeding behavior Fatty acids, omega-3 Diet Cohort studies Animals Adult nuclear magnetic resonance lipoprotein subfractions fish
Abstract: Background Supplementation with omega-3 (n-3) fatty acid or dietary fish may protect against atherosclerosis, but the potential mechanisms are unclear. Prior studies found modest triglyceride-lowering effects and slight increases in LDL (low-density lipoprotein) cholesterol. Limited evidence has examined n-3 effects on more detailed lipoprotein biomarkers. Methods and Results We conducted a study of 26 034 healthy women who reported information on fish and n-3 intake from a 131-item food-frequency questionnaire. We measured plasma lipids, apolipoproteins, and nuclear magnetic resonance spectroscopy lipoproteins and examined their associations with dietary intake of fish, total n-3, and the n-3 subtypes (eicosapentaenoic, docosahexaenoic, and α-linolenic acids). Top- versus bottom-quintile intake of fish and n-3 were significantly associated with lower triglyceride and large VLDL (very-low-density lipoprotein) particles. Fish intake, but not total n-3, was positively associated with total cholesterol, LDL cholesterol, apolipoprotein B, and larger LDL size, but only α-linolenic acid was associated with lower LDL cholesterol. Total n-3, docosahexaenoic acid, and α-linolenic acid intake were also positively associated with larger HDL (high-density lipoprotein) size and large HDL particles. High eicosapentaenoic acid intake was significantly associated with only a decreased level of VLDL particle concentration and VLDL triglyceride content. The n-3 fatty acids had some similarities but also differed in their associations with prospective cardiovascular disease risk patterns. Conclusions Higher consumption of fish and n-3 fatty acids were associated with multiple measures of lipoproteins that were mostly consistent with cardiovascular prevention, with differences noted for high intake of eicosapentaenoic acid versus docosahexaenoic acid and α-linolenic acid that were apparent with more detailed lipoprotein phenotyping. These hypothesis-generating findings warrant further study in clinical trials. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000479.
Thematic Areas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2047-9980
Author's mail: xavier.correig@urv.cat
Author identifier: 0000-0002-6902-3054
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Journal Of The American Heart Association. 9 (5): e014963-
APA: Amigo, Nuria; Akinkuolie, Akintunde O; Chiuve, Stephanie E; Correig, Xavier; Cook, Nancy R; Mora, Samia (2020). Habitual Fish Consumption, n-3 Fatty Acids, and Nuclear Magnetic Resonance Lipoprotein Subfractions in Women. Journal Of The American Heart Association, 9(5), e014963-. DOI: 10.1161/JAHA.119.014963
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV