Author, as appears in the article.: Quesada-Vazquez, Sergio; Aragones, Gerard; Del Bas, Josep M.; Escote, Xavier;

Department: Bioquímica i Biotecnologia

URV's Author/s: Aragonès Bargalló, Gerard / Escote Miro, Xavier

Keywords: Steatohepatitis Obesity Non-alcohol fatty liver disease Nafld Murine model Intestinal bacterial overgrowth Inflammation Gut microbiota Fibrosis Dysbiosis Bile Bacterial translocation Alcohol Akkermansia-muciniphila Acid

Abstract: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression.

Thematic Areas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: gerard.aragones@urv.cat

Record's date: 2023-04-29

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2073-4409/9/1/176

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Cells. 9 (1):

APA: Quesada-Vazquez, Sergio; Aragones, Gerard; Del Bas, Josep M.; Escote, Xavier; (2020). Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis. Cells, 9(1), -. DOI: 10.3390/cells9010176

Article's DOI: 10.3390/cells9010176

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications