Author, as appears in the article.: Rodriguez Chacon, M.; Maymo-Masip, E.; Fernandez-Veledo, S.; Garcia-Espana, A.; Vazquez-Carballo, A.; Tinahones, F.; Garcia-Fuentes, E.; Wabitsch, M.; Vendrell, J.;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Fernandez Veledo, Sonia
Keywords: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
Abstract: Obesity and type 2 diabetes (T2D) are associated with chronic low-grade inflammation. Mounting evidence suggests the involvement of an inflammatory switch in adipose tissue, both in mature adipocytes and immune-competent cells from the stromal vascular compartment, in the progression of obesity and insulin resistance. Several inflammatory cytokines secreted by obese adipose tissue, including TNFα and IL-6 have been described as hallmark molecules involved in this process, impairing insulin signaling in insulin-responsive organs. An increasing number of new molecules affecting the local and systemic inflammatory imbalance in obesity and T2D have been identified. In this complex condition, some molecules may exhibit opposing actions, depending on the cell type and on systemic or local influences. Tumor necrosis factor weak inducer of apoptosis (TWEAK), a cytokine of the tumor necrosis (TNF) superfamily, is gaining attention as an important player in chronic inflammatory diseases. TWEAK can exist as a full-length membrane-associated (mTWEAK) form and as a soluble (sTWEAK) form and, by acting through its cognate receptor Fn14, can control many cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. Notably, sTWEAK has been proposed as a biomarker of cardiovascular diseases. Here, we will review the recent findings relating to TWEAK and its receptor within the context of obesity and the associated disorder T2D.
Thematic Areas: Saúde coletiva Química Psicología Pharmacology & pharmacy Pharmacology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology Farmacia Engenharias iv Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 10233830
Author's mail: sonia.fernandez@urv.cat
Author identifier: 0000-0003-2906-3788
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874549/
Papper original source: Inflammation Research. 60 95-95
APA: Rodriguez Chacon, M.; Maymo-Masip, E.; Fernandez-Veledo, S.; Garcia-Espana, A.; Vazquez-Carballo, A.; Tinahones, F.; Garcia-Fuentes, E.; Wabitsch, M.; (2011). TWEAK MODULATES TNFALPHA INDUCED CYTOKINE PRODUCTION IN HUMAN ADIPOCYTES. Inflammation Research, 60(), 95-95
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3389/fimmu.2013.00488
Entity: Universitat Rovira i Virgili
Journal publication year: 2011
Publication Type: Journal Publications