Homocysteine, the MTHFR 677C>T polymorphism and hypertension: Effect modifiers by lifestyle factors and population subgroups

Author, as appears in the article.: Ornosa-Martin, Gemma; Fernandez-Ballart, Joan D; Ceruelo, Santiago; Rios, Lidia; Ueland, Per M; Meyer, Klaus; Murphy, Michelle M

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Fernández Ballart, Joan Domènech / Murphy, Michelle

Keywords: Risk-factor; Plasma homocysteine; Nutrition examination survey; Mthfr 677c>t polymorphism; Methylenetetrahydrofolate reductase 677c>t polymorphism; Hypertension; Homocysteine; Folic-acid; Folate status; Endothelium-dependent vasodilation; Coronary-artery-disease; Common mutation; Blood-pressure; B vitamins; 3rd national-health; mthfr 677c>t polymorphism; hypertension; homocysteine; b vitamins

Abstract: © The Authors 2020. Evidence linking fasting plasma total homocysteine (tHcy), methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype with hypertension is inconsistent. Differences in B vitamin status, other lifestyle factors, or their consideration in analyses, might explain this. We investigated these associations in the absence of mandatory fortification with folic acid and B vitamin supplement use. A cross-sectional was conducted in 788 adults, aged 18-75 years, randomly selected from 3 Catalonian town population registers. Fasting plasma folate, cobalamin, total homocysteine (tHcy), red blood cell folate, erythrocyte glutathione reductase activation coefficient (EGRAC, functional riboflavin status indicator; increasing EGRAC indicates worsening riboflavin status), MTHFR 677 C>T and solute carrier family 1 (SLC19A1) 80 G>A genotypes were determined. Medical history and lifestyle habits were recorded.Principal tHcy determinants differed between women (age, plasma folate, plasma cobalamin, cigarettes/day) and men (MTHFR 677TT genotype, plasma folate, plasma cobalamin and CT genotype). The MTHFR 677C>T polymorphism-tHcy association (β standardised regression coefficients) was stronger in male smokers (0.52, P < 0.001) compared to nonsmokers (0.21, P = 0.001) and weaker in participants >50 (0.19, P = 0.007) compared to ≤50 years (0.31, P < 0.001). Hypertension was more probable in the 3rd tHcy tertile compared to the other tertiles [OR 1.9 (1.2, 3.0)], and in participants ≤50 years, for the MTHFR 677TT genotype compared to the CC genotype [OR 4.1 (1.0, 16.9)]. EGRAC was associated with increased probability of hypertension in participants >50 years [OR 6.2 (1.0, 38.7)]. In conclusion, moderately elevated tHcy and the MTHFR 677CT genotype were associated with hypertension. The MTHFR 677C>T genotype-hypertension association was confined to adults ≤50 years.

Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Odontología; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Matemática / probabilidade e estatística; Interdisciplinar; General medicine; Farmacia; Engenharias iv; Engenharias ii; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752662

Author's mail: michelle.murphy@urv.cat

Record's date: 2025-02-01

Paper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/homocysteine-the-methylenetetrahydrofolate-reductase-677ct-polymorphism-and-hypertension-effect-modifiers-by-lifestyle-factors-and-population-subgroups/6D8281490EF9F664BC289CE9601C41F6

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: British Journal Of Nutrition. 124 (1): 1-31

APA: Ornosa-Martin, Gemma; Fernandez-Ballart, Joan D; Ceruelo, Santiago; Rios, Lidia; Ueland, Per M; Meyer, Klaus; Murphy, Michelle M (2020). Homocysteine, the MTHFR 677C>T polymorphism and hypertension: Effect modifiers by lifestyle factors and population subgroups. British Journal Of Nutrition, 124(1), 1-31. DOI: 10.1017/S0007114520000793

Article's DOI: 10.1017/S0007114520000793

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications