Articles producció científica> Psicologia

Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring

  • Identification data

    Identifier: imarina:6179224
    Authors:
    Schreiber, ElgaGarcia, TaniaGonzalez, NeusEsplugas, RoserPrasad Sharma, RajuTorrente, MargaritaKumar, VikasBovee, ToineKatsanou, Efrosini SMachera, KyriakiLuis Domingo, JoseGomez, Mercedes
    Abstract:
    © 2020 The Authors Exposure to endocrine-disrupting compounds (EDCs) during pregnancy can result in negative health effects in later generations, including sex changes and feminization. The present study assessed the feminization effects on male offspring rats of three EDCs: Dienestrol (DIES), Linuron (LIN), and Flutamide (FLU). Sexually mature female rats were exposed from gestation day (GD) 6 until postnatal day (PND) 21 to: 0.37, 0.75, 1.5, 3.12 or 6.25 μg/kg/day of DIES, 1.5, 3, 6, 12.5, 25 or 50 mg/kg/day of LIN, 3.5, 6.7, 12.5, 25 or 50 mg/kg/day of FLU, and the following mixtures: FLU + DIES (mg/kg/day+μg/kg/day), 3.5 + 0.37, or 3.5 + 3, 25 + 0.37, or 25 + 3; FLU + LIN (mg/kg/day + mg/kg/day), 3.5 + 12.5, or 25 + 12.5; and DIES + LIN (μg/kg/day + mg/kg/day), 0.37 + 12.5, or 3 + 12.5. Anogenital distance (AGD), nipple retention (NR) and cryptorchidism were evaluated. FLU produced a decrease of AGD, an increase of NR, and an increase of cryptorchidism at the highest dose. None of these three endpoints were significantly affected by LIN or DIES treatments alone. Combinations of FLU + LIN and FLU + DIES increased NR, and decreased AGD, while DIES + LIN did not produce any effects in male pups. Results show that FLU is able to induce feminization in male pups, while binary combinations of LIN and DIES did not modify the effects produced by FLU.
  • Others:

    Author, as appears in the article.: Schreiber, Elga; Garcia, Tania; Gonzalez, Neus; Esplugas, Roser; Prasad Sharma, Raju; Torrente, Margarita; Kumar, Vikas; Bovee, Toine; Katsanou, Efrosini S; Machera, Kyriaki; Luis Domingo, Jose; Gomez, Mercedes
    Department: Enginyeria Química Psicologia
    URV's Author/s: Domingo Roig, José Luis / Esplugas Borràs, Roser / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Kumar, Vikas / Torrente Torné, Margarita
    Keywords: Testis Sexual-differentiation Reproductive development Rats, sprague-dawley Rats Prenatal exposure delayed effects Pregnancy Organ size Nipples Nipple retention Mixtures Maternal exposure Male rats Male Liquid-phase microextraction Linuron Flutamide Feminization effects Feminization Female Extraction sorbent Estrogenic compounds Endpoint determination Endocrine disruptors Dose-response relationship, drug Dienestrol Cryptorchidism Anti-androgens Anogenital distance Animals, newborn Animals Androgen receptor male rats linuron flutamide feminization effects dienestrol
    Abstract: © 2020 The Authors Exposure to endocrine-disrupting compounds (EDCs) during pregnancy can result in negative health effects in later generations, including sex changes and feminization. The present study assessed the feminization effects on male offspring rats of three EDCs: Dienestrol (DIES), Linuron (LIN), and Flutamide (FLU). Sexually mature female rats were exposed from gestation day (GD) 6 until postnatal day (PND) 21 to: 0.37, 0.75, 1.5, 3.12 or 6.25 μg/kg/day of DIES, 1.5, 3, 6, 12.5, 25 or 50 mg/kg/day of LIN, 3.5, 6.7, 12.5, 25 or 50 mg/kg/day of FLU, and the following mixtures: FLU + DIES (mg/kg/day+μg/kg/day), 3.5 + 0.37, or 3.5 + 3, 25 + 0.37, or 25 + 3; FLU + LIN (mg/kg/day + mg/kg/day), 3.5 + 12.5, or 25 + 12.5; and DIES + LIN (μg/kg/day + mg/kg/day), 0.37 + 12.5, or 3 + 12.5. Anogenital distance (AGD), nipple retention (NR) and cryptorchidism were evaluated. FLU produced a decrease of AGD, an increase of NR, and an increase of cryptorchidism at the highest dose. None of these three endpoints were significantly affected by LIN or DIES treatments alone. Combinations of FLU + LIN and FLU + DIES increased NR, and decreased AGD, while DIES + LIN did not produce any effects in male pups. Results show that FLU is able to induce feminization in male pups, while binary combinations of LIN and DIES did not modify the effects produced by FLU.
    Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02786915
    Author's mail: nieves.gonzalez@urv.cat vikas.kumar@urv.cat joseluis.domingo@urv.cat margarita.torrente@urv.cat
    Author identifier: 0000-0003-4134-016X 0000-0002-9795-5967 0000-0001-6647-9470 0000-0002-8901-6345
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0278691520301447
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food And Chemical Toxicology. 139 (111256): 111256-
    APA: Schreiber, Elga; Garcia, Tania; Gonzalez, Neus; Esplugas, Roser; Prasad Sharma, Raju; Torrente, Margarita; Kumar, Vikas; Bovee, Toine; Katsanou, Efros (2020). Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring. Food And Chemical Toxicology, 139(111256), 111256-. DOI: 10.1016/j.fct.2020.111256
    Article's DOI: 10.1016/j.fct.2020.111256
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Testis
    Sexual-differentiation
    Reproductive development
    Rats, sprague-dawley
    Rats
    Prenatal exposure delayed effects
    Pregnancy
    Organ size
    Nipples
    Nipple retention
    Mixtures
    Maternal exposure
    Male rats
    Male
    Liquid-phase microextraction
    Linuron
    Flutamide
    Feminization effects
    Feminization
    Female
    Extraction sorbent
    Estrogenic compounds
    Endpoint determination
    Endocrine disruptors
    Dose-response relationship, drug
    Dienestrol
    Cryptorchidism
    Anti-androgens
    Anogenital distance
    Animals, newborn
    Animals
    Androgen receptor
    male rats
    linuron
    flutamide
    feminization effects
    dienestrol
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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