Author, as appears in the article.: Iglesias–vázquez L; Riba GVG; Arija V; Canals J
Department: Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Arija Val, Maria Victoria / Canals Sans, Josefa / Iglesias Vazquez, Lucia
Keywords: Systematic review and meta-analysis Statement Prevalence Microflora Gut microbiota Gastrointestinal microbiota Dysbiosis Children Autism spectrum disorder Asd Adolescents Acids gut microbiota dysbiosis children autism spectrum disorder asd adolescents
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut–brain microbiota axis suggests that there is a form of communication between microbiota and the brain underlying some neurological disabilities. The aim of this study is to describe and compare the composition of gut microbiota in children with and without ASD. Methods: Electronic databases were searched as far as February 2020. Meta-analyses were performed using RevMan5.3 to estimate the overall relative abundance of gut bacteria belonging to 8 phyla and 17 genera in children with ASD and controls. Results: We included 18 studies assessing a total of 493 ASD children and 404 controls. The microbiota was mainly composed of the phyla Bacteroidetes, Firmicutes, and Actinobacteria, all of which were more abundant in the ASD children than in the controls. Children with ASD showed a significantly higher abundance of the genera Bacteroides, Parabacteroides, Clostridium, Faecalibacterium, and Phascolarctobacterium and a lower percentage of Coprococcus and Bifidobacterium. Discussion: This meta-analysis suggests that there is a dysbiosis in ASD children which may influence the development and severity of ASD symptomatology. Further studies are required in order to obtain stronger evidence of the effectiveness of pre-or probiotics in reducing autistic behaviors.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: lucia.iglesias@urv.cat victoria.arija@urv.cat josefa.canals@urv.cat lucia.iglesias@urv.cat
Author identifier: 0000-0001-7131-4144 0000-0002-1758-0975 0000-0002-6209-9558 0000-0001-7131-4144
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/12/3/792
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 12 (3):
APA: Iglesias–vázquez L; Riba GVG; Arija V; Canals J (2020). Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis. Nutrients, 12(3), -. DOI: 10.3390/nu12030792
Article's DOI: 10.3390/nu12030792
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV