Articles producció científica> Bioquímica i Biotecnologia

The disruption of liver metabolic circadian rhythms by a cafeteria diet is sex-dependent in fischer 344 rats

  • Identification data

    Identifier: imarina:6246717
    Authors:
    Palacios-Jordan HMartín-González MZSuárez MAragonès GMugureza BRodríguez MABladé C
    Abstract:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Circadian rhythms are ~24 h fluctuations of different biological processes that are regulated by the circadian clock system. They exert a major influence on most of the metabolism, such as the hepatic metabolism. This rhythmicity can be disrupted by obesogenic diets, fact that is considered to be a risk factor for the development of metabolic diseases. Nevertheless, obesogenic diets do not affect both genders in the same manner. We hypothesized that the circadian rhythms disruption of the hepatic metabolism, caused by obesogenic diets, is gender-dependent. Male and female Fischer 344 rats were fed either a standard diet or a cafeteria diet and sacrificed at two different moments, at zeitgeber 3 and 15. Only female rats maintained the circadian variations of the hepatic metabolism under a cafeteria diet. Most of those metabolites were related with the very low density lipoprotein (VLDL) synthesis, such as choline, betaine or phosphatidylcholine. Most of these metabolites were found to be increased at the beginning of the dark period. On the other hand, male animals did not show these time differences. These findings suggest that females might be more protected against the circadian disruption of the hepatic metabolism caused by a cafeteria diet through the increase of the VLDL synthesis at the beginning of the feeding time.
  • Others:

    Author, as appears in the article.: Palacios-Jordan H; Martín-González MZ; Suárez M; Aragonès G; Mugureza B; Rodríguez MA; Bladé C
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Aragonès Bargalló, Gerard / BLADÉ SEGARRA, MARIA CINTA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel
    Keywords: Secretion Phosphatidylcholine biosynthesis Obesity Metabolomics Low-density lipoprotein Liver Homocysteine s-methyltransferase Gender Fatty liver Expression Clock Circadian rhythms Choline Betaine metabolomics liver gender circadian rhythms
    Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Circadian rhythms are ~24 h fluctuations of different biological processes that are regulated by the circadian clock system. They exert a major influence on most of the metabolism, such as the hepatic metabolism. This rhythmicity can be disrupted by obesogenic diets, fact that is considered to be a risk factor for the development of metabolic diseases. Nevertheless, obesogenic diets do not affect both genders in the same manner. We hypothesized that the circadian rhythms disruption of the hepatic metabolism, caused by obesogenic diets, is gender-dependent. Male and female Fischer 344 rats were fed either a standard diet or a cafeteria diet and sacrificed at two different moments, at zeitgeber 3 and 15. Only female rats maintained the circadian variations of the hepatic metabolism under a cafeteria diet. Most of those metabolites were related with the very low density lipoprotein (VLDL) synthesis, such as choline, betaine or phosphatidylcholine. Most of these metabolites were found to be increased at the beginning of the dark period. On the other hand, male animals did not show these time differences. These findings suggest that females might be more protected against the circadian disruption of the hepatic metabolism caused by a cafeteria diet through the increase of the VLDL synthesis at the beginning of the feeding time.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    ISSN: 20726643
    Author's mail: gerard.aragones@urv.cat begona.muguerza@urv.cat manuel.suarez@urv.cat
    Author identifier: 0000-0001-7384-8588 0000-0003-0122-8253
    Record's date: 2023-02-22
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/12/4/1085
    Papper original source: Nutrients. 12 (4):
    APA: Palacios-Jordan H; Martín-González MZ; Suárez M; Aragonès G; Mugureza B; Rodríguez MA; Bladé C (2020). The disruption of liver metabolic circadian rhythms by a cafeteria diet is sex-dependent in fischer 344 rats. Nutrients, 12(4), -. DOI: 10.3390/nu12041085
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3390/nu12041085
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Secretion
    Phosphatidylcholine biosynthesis
    Obesity
    Metabolomics
    Low-density lipoprotein
    Liver
    Homocysteine s-methyltransferase
    Gender
    Fatty liver
    Expression
    Clock
    Circadian rhythms
    Choline
    Betaine
    metabolomics
    liver
    gender
    circadian rhythms
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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