Author, as appears in the article.: Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F
Department: Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
Keywords: Sustained attention Repeated acquisition Reaction-time-task Organophosphate pesticide exposure Neurotrophic factor Neurobehavioral performance Methyl parathion exposure Locomotor activity Learning Insecticide chlorpyrifos Inhibitory control Developmental exposure Chlorpyrifos Brain-derived neurotrophic factor Behavioral consequences Attention learning inhibitory control chlorpyrifos brain-derived neurotrophic factor attention
Abstract: Alterations in attention and inhibitory control are common features in several neurological disorders. Environmental factors such as exposure to pesticides have been linked to their appearance. Chlorpyrifos (CPF) is the most widely used organophosphate compound in the world. CPF exposure during development seems to be critical for later behavioral and molecular disruptions during adult ages, although this depends on the specific period of development, where the preweaning period is the least studied. Despite the abundant empirical work made in the last decades on developmental CPF exposure, the systematic study of this on attention is sparse, and nonexistent concerning inhibitory control, without a single study on preweaning developmental stages. The present research explored the effects of the exposure to low doses of CPF that do not elicit a significant inhibition of the Cholinesterases during this developmental period on rats' behavior in the five-choice serial reaction time task. Behavioral manipulations (inter-trial interval and stimulus duration), pharmacological manipulations (cholinergic and GABAergic drugs) and brain gene expression analyses were also conducted. Exposure to CPF decreased the locomotor activity and enhanced the learning profile of the female rats, increased the impulsive rates, unmasked by a longer inter-trial interval, hypo-sensitized the cholinergic system and down-regulated the mRNA expression levels of the brain-derived neurotrophic factor in the dorsal striatum of the male rats. This happened without significant inhibition of the brain Acetylcholinesterase. All this new information corroborates that the exposure to a common pesticide at low doses during a key, but under-explored developmental period importantly affects different behaviors, neurotransmitter systems, and molecules that are altered in the main neurological disorders observed nowadays.Copyright © 2020. Published by Elsevier Inc.
Thematic Areas: Química Psicología Nutrição Neurosciences Neurology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Developmental neuroscience Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0014-4886
Author's mail: mariateresa.colomina@urv.cat
Author identifier: 0000-0002-5619-4874
Record's date: 2024-06-15
Journal volume: 330
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0014488620301874?via%3Dihub
Papper original source: Experimental Neurology. 330 (113356): 113356-113356
APA: Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F (2020). Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression. Experimental Neurology, 330(113356), 113356-113356. DOI: 10.1016/j.expneurol.2020.113356
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.expneurol.2020.113356
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV