Articles producció científica> Ciències Mèdiques Bàsiques

Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?

  • Identification data

    Identifier: imarina:6310799
    Authors:
    Roedel, FranzArenas, MeritxellOtt, Oliver J.Fournier, ClaudiaGeorgakilas, Alexandros G.Tapio, SoileTrott, Klaus-RuedigerGaipl, Udo S.
    Abstract:
    In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 & x202f;Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 & x202f;Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
  • Others:

    Author, as appears in the article.: Roedel, Franz; Arenas, Meritxell; Ott, Oliver J.; Fournier, Claudia; Georgakilas, Alexandros G.; Tapio, Soile; Trott, Klaus-Ruediger; Gaipl, Udo S.;
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell
    Keywords: anti-inflammatory covid-19 low-dose radiation therapy pneumonia Anti-inflammatory Covid-19 Induction Low-dose radiation therapy Pneumonia Radiotherapy Repair Sars-cov-2
    Abstract: In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 & x202f;Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 & x202f;Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
    Thematic Areas: General medicine Oncology Radiology, nuclear medicine & medical imaging Radiology, nuclear medicine and imaging
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: meritxell.arenas@urv.cat
    ISSN: 1439099X
    Author identifier: 0000-0003-0815-2570
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://link.springer.com/article/10.1007/s00066-020-01635-7
    Papper original source: Strahlentherapie Und Onkologie. 196 (8): 679-682
    APA: Roedel, Franz; Arenas, Meritxell; Ott, Oliver J.; Fournier, Claudia; Georgakilas, Alexandros G.; Tapio, Soile; Trott, Klaus-Ruediger; Gaipl, Udo S.; (2020). Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?. Strahlentherapie Und Onkologie, 196(8), 679-682. DOI: 10.1007/s00066-020-01635-7
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1007/s00066-020-01635-7
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Oncology,Radiology, Nuclear Medicine & Medical Imaging,Radiology, Nuclear Medicine and Imaging
    anti-inflammatory
    covid-19
    low-dose radiation therapy
    pneumonia
    Anti-inflammatory
    Covid-19
    Induction
    Low-dose radiation therapy
    Pneumonia
    Radiotherapy
    Repair
    Sars-cov-2
    General medicine
    Oncology
    Radiology, nuclear medicine & medical imaging
    Radiology, nuclear medicine and imaging
    1439099X
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