Author, as appears in the article.: Autrup H; Barile FA; Berry SC; Blaauboer BJ; Boobis A; Bolt H; Borgert CJ; Dekant W; Dietrich D; Domingo JL; Gori GB; Greim H; Hengstler J; Kacew S; Marquardt H; Pelkonen O; Savolainen K; Heslop-Harrison P; Vermeulen NP
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis
Keywords: endocrine disruption risk characterisation Bisphenol-a Endocrine disruption Estrogens Eu Human health Modulators Risk characterisation Science Testing Uncertainty
Abstract: © 2020 Elsevier B.V. Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
Thematic Areas: Astronomia / física Biodiversidade Biotecnología Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Engenharias ii Ensino Environmental sciences Farmacia Geociências Geografía Health, toxicology and mutagenesis Interdisciplinar Materiais Medicina i Medicina ii Medicina veterinaria Medicine (miscellaneous) Odontología Pharmacology Pharmacology & pharmacy Psicología Química Toxicology Zootecnia / recursos pesqueiros
Author's mail: joseluis.domingo@urv.cat
ISSN: 13826689
Author identifier: 0000-0001-6647-9470
Record's date: 2023-02-22
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1382668920300727?via%3Dihub
Papper original source: Environmental Toxicology And Pharmacology. 78 (103396): 103396-
APA: Autrup H; Barile FA; Berry SC; Blaauboer BJ; Boobis A; Bolt H; Borgert CJ; Dekant W; Dietrich D; Domingo JL; Gori GB; Greim H; Hengstler J; Kacew S; M (2020). Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Environmental Toxicology And Pharmacology, 78(103396), 103396-. DOI: 10.1016/j.etap.2020.103396
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.etap.2020.103396
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV