Author, as appears in the article.: Galie, Serena; Canudas, Silvia; Muralidharan, Jananee; Garcia-Gavilan, Jesus; Bullo, Monica; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Galiè, Serena / García Gavilán, Jesús Francisco / Muralidharan, Jananee / Salas Salvadó, Jorge
Project code: Grant agreement No. 713679
Keywords: Telomere shortening Telomere length Telomere Telomerase Randomized controlled trials as topic Oxidative stress Nutritional status National-health Micronutrients Mediterranean diet Macronutrients Length Humans Food groups Food Fatty-acids Dna-damage Dietary pattern Cohort studies Coffee consumption Cardiovascular-disease 25-hydroxyvitamin d telomerase micronutrients macronutrients food dietary pattern
Abstract: Copyright © The Author(s) 2019. Diet, physical activity, and other lifestyle factors have been implicated in the pathophysiology of several chronic diseases, but also in a lower total mortality and longer life expectancy. One of the mechanisms in which diet can reduce the risk of disease is with regard to its impact on telomeres. Telomere length (TL) is highly correlated to chronological age and metabolic status. Individuals with shorter telomeres are at higher risk of chronic diseases and mortality. Diet may influence TL by several mechanisms such as regulating oxidative stress and inflammation or modulating epigenetic reactions. The present systematic review aims to examine the results from epidemiologic and clinical trials conducted in humans evaluating the role of nutrients, food groups, and dietary patterns on TL. We also discuss the possible mechanisms of action that influence this process, with the perspective that TL could be a novel biomarker indicating the risk of metabolic disturbances and age-related diseases. The available evidence suggests that some antioxidant nutrients, the consumption of fruits and vegetables, and Mediterranean diet are mainly associated with longer telomeres. However, most of the evidence is based on high heterogenic observational studies and very few randomized clinical trials (RCTs). Therefore, the associations summarized in the present review need to be confirmed with larger prospective cohort studies and better-designed RCTs.
Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina ii Food science Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 21565376
Author's mail: jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://academic.oup.com/advances/article/11/3/576/5613358?login=false
Funding program: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Advances In Nutrition. 11 (3): 576-601
APA: Galie, Serena; Canudas, Silvia; Muralidharan, Jananee; Garcia-Gavilan, Jesus; Bullo, Monica; Salas-Salvado, Jordi (2020). Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials. Advances In Nutrition, 11(3), 576-601. DOI: 10.1093/advances/nmz107
Acronym: MFP
Article's DOI: 10.1093/advances/nmz107
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Funding program action: Martí i Franquès COFUND Doctoral Programme
Publication Type: Journal Publications
Repositori URV