Author, as appears in the article.: Salas-Salvado, Jordi; Farres, Xavier; Luque, Xavier; Narejos, Silvia; Borrell, Manel; Basora, Josep; Anguera, Anna; Torres, Ferran; Bullo, Monica; Balanza, Rafel
Department: Bioquímica i Biotecnologia
URV's Author/s: Balanza Roure, Rafael Juan / Basora Gallisa, Josep / Bulló Bonet, Mònica / CASAS AGUSTENCH, PATRICIA / Salas Salvadó, Jorge
Keywords: Plantago Lipid profile Glucomannan Dietary fibre Body weight
Abstract: The aim of the study was to compare the effect of the administration of a mixture of fibres on body weight-loss, satiety, lipid profile and glucose metabolism. We included 200 overweight or obese patients in a parallel, double-blind, placebo-controlled clinical trial, who were randomised to receive, in the context of an energy-restricted diet for a period of 16 weeks, a mixed fibre dose (3 g Plantago ovata husk and 1 g glucomannan) twice (b.i.d. group) or three times daily (t.i.d. group) or placebo. Weight change was the primary efficacy endpoint. Satiety, dietary compliance, lipid profile, glucose tolerance, insulin resistance and high-sensitivity C-reactive protein were secondary endpoints. Weight loss tended to be higher after both doses of fibre (-4.52 (SD 0.56) and -4.60 (SD 0.55) kg) than placebo (-0.79 (SD 0.58) kg); the differences in changes between groups were not statistically significant. Postprandial satiety increased in both fibre groups compared to the placebo. The differences between groups in LDL-cholesterol levels were significant (P = 0.03), with greater reductions in the two fibre-supplemented groups (-0.38 (SD 0.10) and -0.24 (SD 0.09) mmol/l in the b.i.d. and t.i.d. groups v. -0.06 (SD 0.09) mmol/l in placebo group). A similar pattern was observed for changes in total cholesterol:HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratios. Interventions were well tolerated and had no effects on HDL-cholesterol, glucose and insulin concentrations, glucose tolerance or high-sensitivity C-reactive protein. In conclusion, a 16-week dietary supplement of soluble fibre in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some CVD risk factors, the most important of which was a significant decrease in plasma LDL-cholesterol concentrations. © The Authors 2007.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Author's mail: josep.basora@urv.cat rafaeljuan.balanza@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: British Journal Of Nutrition. 99 (6): 1380-1387
APA: Salas-Salvado, Jordi; Farres, Xavier; Luque, Xavier; Narejos, Silvia; Borrell, Manel; Basora, Josep; Anguera, Anna; Torres, Ferran; Bullo, Monica; Bal (2008). Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: A randomised trial. British Journal Of Nutrition, 99(6), 1380-1387. DOI: 10.1017/S0007114507868528
Entity: Universitat Rovira i Virgili
Journal publication year: 2008
Publication Type: Journal Publications
Repositori URV