Author, as appears in the article.: Marsillach J; Camps J; Ferré N; Beltran R; Rull A; Mackness B; Mackness M; Joven J
Department: Medicina i Cirurgia
URV's Author/s: Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Ferré Huguet, Núria / Ferre Pallas, Natalia / Joven Maried, Jorge / MARSILLACH LÓPEZ, JUDIT / RULL AIXA, ANNA
Abstract: Background: Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1). We investigated the relationships between hepatic PON1 and MCP-1 expression in rats with liver disease and explored the possible molecular mechanisms involved. Methods: CCl4 was administered for up to 12 weeks to induce liver damage. Serum and hepatic levels of PON1 and MCP-1, their gene and protein expression, nuclear transcription factors, and histological and biochemical markers of liver impairment were measured. Results: High levels of PON1 and MCP-1 expression were observed at 12th week in the hepatocytes surrounding the fibrous septa and inflammatory areas. CCl4-administered rats had an increased hepatic PON1 concentration that was related to decreased gene transcription and inhibited protein degradation. Decreased PON1 gene transcription was associated with PPARδ expression. These changes were accompanied by increased hepatic MCP-1 concentration and gene expression. There were significant direct relationships between hepatic PON1 and MCP-1 concentrations (P = 0.005) and between PON1 and the amount of activated stellate cells (P = 0.001). Conclusion: Our results from this experimental model suggest a hepato-protective role for PON1 against inflammation, fibrosis and liver disease mediated by MCP-1. © 2009 Marsillach et al; licensee BioMed Central Ltd.
Thematic Areas: Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Gastroenterology & hepatology Gastroenterology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1471-230X
Author's mail: nuria.ferre@urv.cat jorge.camps@urv.cat jorge.joven@urv.cat natalia.ferre@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541 0000-0002-2838-1525 0000-0001-9691-1906
Record's date: 2024-09-07
Journal volume: 9
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-9-3
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Gastroenterology. 9 3-
APA: Marsillach J; Camps J; Ferré N; Beltran R; Rull A; Mackness B; Mackness M; Joven J (2009). Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. Bmc Gastroenterology, 9(), 3-. DOI: 10.1186/1471-230X-9-3
Article's DOI: 10.1186/1471-230X-9-3
Entity: Universitat Rovira i Virgili
Journal publication year: 2009
Publication Type: Journal Publications