Articles producció científica> Medicina i Cirurgia

Evaluation of oxidative stress biomarkers in patients with chronic renal failure: A case control study

  • Identification data

    Identifier: imarina:6386225
    Authors:
    Romeu MNogues RMarcas LSnchez-Martos VMulero MMartinez-Vea AMallol JGiralt M
    Abstract:
    Background. Oxidative stress is related to several diseases, including chronic renal insufficiency. The disequilibrium in the oxidant-antioxidant balance is the result of several metabolic changes. The majority of studies to-date have evaluated the grade of oxidative stress with a single biomarker, or a very limited number of them. Findings. The present study used several important biomarkers to establish a score relating to oxidative stress status (glutathione S-transferase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced and oxidized glutathione, thiobarbituric acid reactive substances and hemolysis test). The score of oxidative stress (SOS) was then applied to a group of patients with renal insufficiency not on hemodialysis, and compared to healthy control individuals. The score for patients with chronic renal insufficiency was significantly different from that of the healthy control group (0.62 1.41 vs. -0.05 0.94; p < 0.001). The comparison between patients with chronic renal insufficiency and control individuals showed significant differences with respect to changes in the enzymatic antioxidant systems (glutathione S-transferase, glutathione reductase), non-enzymatic antioxidant system (oxidized glutathione) and oxidizability (hemolysis test) indicating significant oxidative stress associated with chronic renal insufficiency. Conclusions. Patients with chronic renal insufficiency not on hemodialysis are susceptible to oxidative stress. The mechanisms that underlie this status are the consequence of changes in glutathione and related enzymes. The SOS scoring system is a useful biochemical parameter to evaluate the influence of oxidative stress on the clinical status of these patients. © 2010 Giralt et al; licensee BioMed Centr
  • Others:

    Author, as appears in the article.: Romeu M; Nogues R; Marcas L; Snchez-Martos V; Mulero M; Martinez-Vea A; Mallol J; Giralt M
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    URV's Author/s: Giralt Batista, Montserrat / Giralt Esteve, Mireia / MALLOL MIRÓN, JORGE / Martínez Vea, Alberto / Mulero Abellán, Miguel / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / ROMEU FIGUEROLA, MARIA CARMEN / Sánchez Martos, Vanessa
    Keywords: Insuficiencia renal crónica Estrès oxidatiu
    Abstract: Background. Oxidative stress is related to several diseases, including chronic renal insufficiency. The disequilibrium in the oxidant-antioxidant balance is the result of several metabolic changes. The majority of studies to-date have evaluated the grade of oxidative stress with a single biomarker, or a very limited number of them. Findings. The present study used several important biomarkers to establish a score relating to oxidative stress status (glutathione S-transferase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced and oxidized glutathione, thiobarbituric acid reactive substances and hemolysis test). The score of oxidative stress (SOS) was then applied to a group of patients with renal insufficiency not on hemodialysis, and compared to healthy control individuals. The score for patients with chronic renal insufficiency was significantly different from that of the healthy control group (0.62 1.41 vs. -0.05 0.94; p < 0.001). The comparison between patients with chronic renal insufficiency and control individuals showed significant differences with respect to changes in the enzymatic antioxidant systems (glutathione S-transferase, glutathione reductase), non-enzymatic antioxidant system (oxidized glutathione) and oxidizability (hemolysis test) indicating significant oxidative stress associated with chronic renal insufficiency. Conclusions. Patients with chronic renal insufficiency not on hemodialysis are susceptible to oxidative stress. The mechanisms that underlie this status are the consequence of changes in glutathione and related enzymes. The SOS scoring system is a useful biochemical parameter to evaluate the influence of oxidative stress on the clinical status of these patients. © 2010 Giralt et al; licensee BioMed Central Ltd.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Multidisciplinary sciences Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geografía General medicine General biochemistry,genetics and molecular biology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Antropologia / arqueologia Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 17560500
    Author's mail: alberto.martinez@urv.cat montse.giralt@urv.cat vanessa.sanchez@urv.cat vanessa.sanchez@urv.cat miquel.mulero@urv.cat marta.romeu@urv.cat
    Author identifier: 0000-0002-0819-8096 0000-0002-7073-577X 0000-0002-2131-1858
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-3-20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bmc Research Notes. 3 20-
    APA: Romeu M; Nogues R; Marcas L; Snchez-Martos V; Mulero M; Martinez-Vea A; Mallol J; Giralt M (2010). Evaluation of oxidative stress biomarkers in patients with chronic renal failure: A case control study. Bmc Research Notes, 3(), 20-. DOI: 10.1186/1756-0500-3-20
    Article's DOI: 10.1186/1756-0500-3-20
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2010
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Multidisciplinary Sciences
    Insuficiencia renal crónica
    Estrès oxidatiu
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Multidisciplinary sciences
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geografía
    General medicine
    General biochemistry,genetics and molecular biology
    Farmacia
    Engenharias iv
    Engenharias iii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Antropologia / arqueologia
    Administração pública e de empresas, ciências contábeis e turismo
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