Articles producció científica> Bioquímica i Biotecnologia

Proanthocyanidins modulate triglyceride secretion by repressing the expression of long chain acyl-CoA synthetases in Caco2 intestinal cells

  • Identification data

    Identifier: imarina:6386705
    Authors:
    Quesada, HPajuelo, DFernandez-Iglesias, ADiaz, SArdevol, ABlay, MSalvado, M JArola, LBlade, C
    Abstract:
    In this work we determined the ability of grape seed proanthocyanidins (GSPE) to modulate triglyceride (TG) secretion by enterocytes in post-prandial and fasting states, using Caco2 cell line. GSPE did not modify TG secretion in the post-prandial state, even though it modulated the long chain acyl-CoA synthetase (ACSL) 5 and the carnitine-palmitoyl-transferase-1a gene expression. On the contrary, GSPE decreased TG secretion in the fasting state, significantly repressing ACSL3, ACSL5, I-FABP and PPARalpha gene expression. Intestinal cells can use two different pathways to carry out TG synthesis. Fatty acids (FA) delivered by ACSL3 and by ACSL5 would be directed towards the monoacylglycerol and glycerol-3-phosphate pathways, respectively. Therefore, proanthocyanidins repress the supply of FA towards the monoacylglycerol pathway in the post-prandial state, whereas they repress the supply of FAs towards both pathways in the fasting state, suggesting that the feeding state is a key factor regarding the effectiveness of proanthocyanidins to reduce triglyceridaemia. © 2011 Elsevier Ltd. All rights reserved.
  • Others:

    Author, as appears in the article.: Quesada, H; Pajuelo, D; Fernandez-Iglesias, A; Diaz, S; Ardevol, A; Blay, M; Salvado, M J; Arola, L; Blade, C
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / Blay Olivé, Maria Teresa / DÍAZ MARTÍNEZ, SABINA / Fernández Iglesias, Anabel / PAJUELO REGUERA, DAVID / QUESADA VAZQUEZ, HELENA / Salvadó Rovira, Maria Josepa
    Keywords: Triglyceride Pparalpha Intestine Flavonoids Acsl
    Abstract: In this work we determined the ability of grape seed proanthocyanidins (GSPE) to modulate triglyceride (TG) secretion by enterocytes in post-prandial and fasting states, using Caco2 cell line. GSPE did not modify TG secretion in the post-prandial state, even though it modulated the long chain acyl-CoA synthetase (ACSL) 5 and the carnitine-palmitoyl-transferase-1a gene expression. On the contrary, GSPE decreased TG secretion in the fasting state, significantly repressing ACSL3, ACSL5, I-FABP and PPARalpha gene expression. Intestinal cells can use two different pathways to carry out TG synthesis. Fatty acids (FA) delivered by ACSL3 and by ACSL5 would be directed towards the monoacylglycerol and glycerol-3-phosphate pathways, respectively. Therefore, proanthocyanidins repress the supply of FA towards the monoacylglycerol pathway in the post-prandial state, whereas they repress the supply of FAs towards both pathways in the fasting state, suggesting that the feeding state is a key factor regarding the effectiveness of proanthocyanidins to reduce triglyceridaemia. © 2011 Elsevier Ltd. All rights reserved.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 03088146
    Author's mail: anna.ardevol@urv.cat mteresa.blay@urv.cat lluis.arola@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0002-6256-9847 0000-0003-2767-1974
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0308814611008284
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food Chemistry. 129 (4): 1490-1494
    APA: Quesada, H; Pajuelo, D; Fernandez-Iglesias, A; Diaz, S; Ardevol, A; Blay, M; Salvado, M J; Arola, L; Blade, C (2011). Proanthocyanidins modulate triglyceride secretion by repressing the expression of long chain acyl-CoA synthetases in Caco2 intestinal cells. Food Chemistry, 129(4), 1490-1494. DOI: 10.1016/j.foodchem.2011.05.125
    Article's DOI: 10.1016/j.foodchem.2011.05.125
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2011
    Publication Type: Journal Publications
  • Keywords:

    Analytical Chemistry,Chemistry, Applied,Food Science,Food Science & Technology,Medicine (Miscellaneous),Nutrition & Dietetics
    Triglyceride
    Pparalpha
    Intestine
    Flavonoids
    Acsl
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geociências
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, applied
    Biotecnología
    Biodiversidade
    Astronomia / física
    Analytical chemistry
    Administração pública e de empresas, ciências contábeis e turismo
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