Author, as appears in the article.: Quesada H; Pajuelo D; Fernández-Iglesias A; Díaz S; Ardevol A; Blay M; Salvadó M; Arola L; Blade C

Department: Bioquímica i Biotecnologia

URV's Author/s: Ardèvol Grau, Anna / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / Blay Olivé, Maria Teresa / Fernández Iglesias, Anabel / QUESADA VAZQUEZ, HELENA / Salvadó Rovira, Maria Josepa

Keywords: Triglyceride Pparalpha Intestine Flavonoids Acsl

Abstract: In this work we determined the ability of grape seed proanthocyanidins (GSPE) to modulate triglyceride (TG) secretion by enterocytes in post-prandial and fasting states, using Caco2 cell line. GSPE did not modify TG secretion in the post-prandial state, even though it modulated the long chain acyl-CoA synthetase (ACSL) 5 and the carnitine-palmitoyl-transferase-1a gene expression. On the contrary, GSPE decreased TG secretion in the fasting state, significantly repressing ACSL3, ACSL5, I-FABP and PPARalpha gene expression. Intestinal cells can use two different pathways to carry out TG synthesis. Fatty acids (FA) delivered by ACSL3 and by ACSL5 would be directed towards the monoacylglycerol and glycerol-3-phosphate pathways, respectively. Therefore, proanthocyanidins repress the supply of FA towards the monoacylglycerol pathway in the post-prandial state, whereas they repress the supply of FAs towards both pathways in the fasting state, suggesting that the feeding state is a key factor regarding the effectiveness of proanthocyanidins to reduce triglyceridaemia. © 2011 Elsevier Ltd. All rights reserved.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 03088146

Author's mail: lluis.arola@urv.cat mariajosepa.salvado@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Author identifier: 0000-0003-2767-1974 0000-0003-3883-3326 0000-0002-6256-9847 0000-0003-0156-7538

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0308814611008284

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Food Chemistry. 129 (4): 1490-1494

APA: Quesada H; Pajuelo D; Fernández-Iglesias A; Díaz S; Ardevol A; Blay M; Salvadó M; Arola L; Blade C (2011). Proanthocyanidins modulate triglyceride secretion by repressing the expression of long chain acyl-CoA synthetases in Caco2 intestinal cells. Food Chemistry, 129(4), 1490-1494. DOI: 10.1016/j.foodchem.2011.05.125

Article's DOI: 10.1016/j.foodchem.2011.05.125

Entity: Universitat Rovira i Virgili

Journal publication year: 2011

Publication Type: Journal Publications