Articles producció científicaMedicina i Cirurgia

Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension

  • Identification data

    Identifier:  imarina:6387078
    Handle: https://hdl.handle.net/20.500.11797/imarina6387078
    Authors:  Vallve, Joan-Carles; Serra, Noemi; Zalba, Guillermo; Fortuno, Ana; Beloqui, Oscar; Ferre, Raimon; Ribalta, Josep; Masana, Lluis
    Abstract:
    Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension. © 2012 Vallvé et al.

  • Others:

    Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043051
    APA: Vallve, Joan-Carles; Serra, Noemi; Zalba, Guillermo; Fortuno, Ana; Beloqui, Oscar; Ferre, Raimon; Ribalta, Josep; Masana, Lluis (2012). Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. Plos One, 7(8), e43051-e43051. DOI: 10.1371/journal.pone.0043051
    Paper original source: Plos One. 7 (8): e43051-e43051
    Article's DOI: 10.1371/journal.pone.0043051
    Journal publication year: 2012
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2025-02-18
    URV's Author/s: FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Ribalta Vives, Josep / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
    Department: Medicina i Cirurgia, Ciències Mèdiques Bàsiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 19326203
    Author, as appears in the article.: Vallve, Joan-Carles; Serra, Noemi; Zalba, Guillermo; Fortuno, Ana; Beloqui, Oscar; Ferre, Raimon; Ribalta, Josep; Masana, Lluis
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Zootecnia / recursos pesqueiros, Sociology, Sociología, Serviço social, Saúde coletiva, Química, Psychology, Psicología, Planejamento urbano e regional / demografia, Odontología, Nutrição, Multidisciplinary sciences, Multidisciplinary, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Linguística e literatura, Letras / linguística, Interdisciplinary research in the social sciences, Interdisciplinar, Human geography and urban studies, History & philosophy of science, Historia, Geografía, Geociências, General medicine, General biochemistry,genetics and molecular biology, General agricultural and biological sciences, Farmacia, Environmental studies, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Enfermagem, Educação física, Educação, Economia, Direito, Demography, Comunicação e informação, Ciências sociais aplicadas i, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência política e relações internacionais, Ciência de alimentos, Ciência da computação, Biotecnología, Biology, Biodiversidade, Biochemistry, genetics and molecular biology (miscellaneous), Astronomia / física, Arquitetura, urbanismo e design, Archaeology, Antropologia / arqueologia, Anthropology, Agricultural and biological sciences (miscellaneous), Administração, ciências contábeis e turismo, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: jc.vallve@urv.cat, noemi.serra@urv.cat, jc.vallve@urv.cat, luis.masana@urv.cat, josep.ribalta@urv.cat

  • Keywords:

    White people
    Vascular stiffness
    Spain
    Regression analysis
    Polymorphism
    single nucleotide
    Odds ratio
    Hypertension
    Humans
    Good health and well-being
    Genotype
    Genetic predisposition to disease
    Genetic association studies
    Gene frequency
    Fibulin 2
    Extracellular matrix proteins
    Case-control studies
    Calcium-binding proteins
    Blood pressure
    Analysis of variance
    Agricultural and Biological Sciences (Miscellaneous)
    Biochemistry
    Genetics and Molecular Biology (Miscellaneous)
    Biology
    Medicine (Miscellaneous)
    Multidisciplinary
    Multidisciplinary Sciences
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry
    genetics and molecular biology
    General agricultural and biological sciences
    Farmacia
    Environmental studies
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Demography
    Comunicação e informação
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura
    urbanismo e design
    Archaeology
    A

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