Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension

Author, as appears in the article.: Vallve, Joan-Carles; Serra, Noemi; Zalba, Guillermo; Fortuno, Ana; Beloqui, Oscar; Ferre, Raimon; Ribalta, Josep; Masana, Lluis

Department: Medicina i Cirurgia; Ciències Mèdiques Bàsiques

URV's Author/s: FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Ribalta Vives, Josep / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles

Keywords: White people; Vascular stiffness; Spain; Regression analysis; Polymorphism, single nucleotide; Odds ratio; Hypertension; Humans; Good health and well-being; Genotype; Genetic predisposition to disease; Genetic association studies; Gene frequency; Fibulin 2; Extracellular matrix proteins; Case-control studies; Calcium-binding proteins; Blood pressure; Analysis of variance

Abstract: Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension. © 2012 Vallvé et al.

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licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Author's mail: jc.vallve@urv.cat; noemi.serra@urv.cat; jc.vallve@urv.cat; luis.masana@urv.cat; josep.ribalta@urv.cat

Record's date: 2025-02-18

Paper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043051

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Plos One. 7 (8): e43051-e43051

APA: Vallve, Joan-Carles; Serra, Noemi; Zalba, Guillermo; Fortuno, Ana; Beloqui, Oscar; Ferre, Raimon; Ribalta, Josep; Masana, Lluis (2012). Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. Plos One, 7(8), e43051-e43051. DOI: 10.1371/journal.pone.0043051

Article's DOI: 10.1371/journal.pone.0043051

Entity: Universitat Rovira i Virgili

Journal publication year: 2012

Publication Type: Journal Publications