Author, as appears in the article.: Blade, Cinta; Baselga-Escudero, Laura; Josepa Salvado, Maria; Arola-Arnal, Anna
Department: Bioquímica i Biotecnologia
URV's Author/s: Arola Arnal, Anna / BASELGA ESCUDERO, LAURA / BLADÉ SEGARRA, MARIA CINTA / Salvadó Rovira, Maria Josepa
Keywords: Polyphenols; Obesity; Non-alcoholic fatty liver disease; Micrornas; Microrna; Lipid metabolism; Insulin; Humans; Glucose; Gene expression regulation; Fatty liver; Diabetes mellitus, type 2; Chronic disease; Cardiovascular diseases; Cardiovascular; Biomarkers; Amino acids; Adipogenesis
Abstract: MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18-25 nucleotides in length, that modulate gene expression at the posttranscriptional level. Thousands of miRNAs have been described, and it is thought that they regulate some aspects of more than 60% of all human cell transcripts. Several polyphenols have been shown to modulate miRNAs related to metabolic homeostasis and chronic diseases. Polyphenolic modulation of miRNAs is very attractive as a strategy to target numerous cell processes and potentially reduce the risk of chronic disease. Evidence is building that polyphenols can target specific miRNAs, such as miR-122, but more studies are necessary to discover and validate additional miRNA targets. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Thematic Areas: Saúde coletiva; Química; Nutrição; Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Food science & technology; Food science; Farmacia; Educação física; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biotechnology; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Author's mail: anna.arola@urv.cat
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201200454
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Molecular Nutrition & Food Research. 57 (1): 58-70
APA: Blade, Cinta; Baselga-Escudero, Laura; Josepa Salvado, Maria; Arola-Arnal, Anna (2013). miRNAs, polyphenols, and chronic disease. Molecular Nutrition & Food Research, 57(1), 58-70. DOI: 10.1002/mnfr.201200454
Article's DOI: 10.1002/mnfr.201200454
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications
Repositori URV