Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Author, as appears in the article.: Romeu, Marta; Aranda, Nuria; Giralt, Montserrat; Ribot, Blanca; Rosa Nogues, Maria; Arija, Victoria

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Giralt Batista, Montserrat / Nogués Llort, Maria Rosa / RIBOT SERRA, BLANCA / Romeu Ferran, Marta

Keywords: Young adult; Spain; Seafood; Prospective studies; Plasma; Oxidative stress; Obesity; Mortality; Middle aged; Meat; Malondialdehyde; Male; Lipids; Lipid peroxidation; Iron, dietary; Iron; Iowa womens health; Inflammation; Humans; Heme; General population; Fishes; Ferritin; Female; Dietary fats; Diet, mediterranean; Diet; Cross-sectional studies; Consumption; Biomarkers; Antioxidants; Antioxidant status; Animals; Aging; Aged; Adult; Adolescent

Abstract: Background: The consumption pattern characterized by high consumption of vegetables, fruit, fish, olive oil and red wine has been associated with improvements in the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation. Also, high body iron levels may contribute to increase the oxidative stress by the generation of reactive oxygen species. The objective of this study is to analyze the relationship between antioxidant and pro-oxidant factors obtained from the diet and iron biomarkers on lipoprotein oxidation and total antioxidant capacity in a representative sample of the Mediterranean population. Methods. Cross-sectional prospective study, carried out with 815 randomly selected subjects (425 women and 390 men). Dietary assessment (3-day food records), iron biomarkers (serum ferritin, serum iron and transferrin saturation), biochemical markers of lipoperoxidation (TBARS), antioxidant capacity (ORAC) and CRP (C-Reactive Protein) were determined. Multiple Linear Regression (MLR) models were applied to analyze the association between diet factors and iron biomarkers on TBARS and ORAC levels. Results: We observed that lipoperoxidation measured by TBARS increased by age but no differences were observed by sex. Antioxidant capacity measured by ORAC is independent of age and sex. In general, increasing age, tobacco, heme iron intake from meat and fish and transferrin saturation were independently and positively associated with TBARS, while non-heme iron was negatively associated. Vegetables, vitamin C intake and serum ferritin were positively associated with ORAC, whereas saturated fatty acids and meat intake were negatively associated. Conclusions: In our general population, we observed that oxidative stress is related to aging, but antioxidant capacity is not. The highest intake of dietary non-heme iron, vegetables and vitamin C intake exerts a protective effect against oxidation while the highest intake of dietary heme iron from meat and fish and saturated fatty acids are associated with increased oxidative stress. High levels of circulating iron measured by transferrin saturation are associated with increased oxidative stress in women however its association with the higher levels of serum ferritin is controversial. © 2013 Romeu et al.; licensee BioMed Central Ltd.

Thematic Areas: Serviço social; Saúde coletiva; Química; Psicología; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Farmacia; Ensino; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752891

Author's mail: nuria.aranda@urv.cat; montse.giralt@urv.cat; marta.romeu@urv.cat; victoria.arija@urv.cat

Record's date: 2025-02-08

Paper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-102

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Nutrition Journal. 12 (1): 102-

APA: Romeu, Marta; Aranda, Nuria; Giralt, Montserrat; Ribot, Blanca; Rosa Nogues, Maria; Arija, Victoria (2013). Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population. Nutrition Journal, 12(1), 102-. DOI: 10.1186/1475-2891-12-102

Article's DOI: 10.1186/1475-2891-12-102

Entity: Universitat Rovira i Virgili

Journal publication year: 2013

Publication Type: Journal Publications