Author, as appears in the article.: Candido Fernandez-Cao, Jose; Arija, Victoria; Aranda, Nuria; Bullo, Monica; Basora, Josep; Angel Martinez-Gonzalez, Miguel; Diez-Espino, Javier; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Bulló Bonet, Mònica / Salas Salvadó, Jorge
Abstract: Background: Several epidemiological studies have observed an increased risk of type 2 diabetes mellitus (T2DM) among subjects with a higher consumption of red and processed meat. Heme iron intake has been directly associated with a higher risk of T2DM in healthy adult Chinese and U.S populations. The objective of the present study was to evaluate the association between heme iron intake and the incidence of T2DM in a Mediterranean population at high cardiovascular risk. Methods. We assessed a subset of participants in the PREDIMED trial as an observational cohort, followed up for a maximum of eight years. We initially included 1073 non-diabetic subjects (57.1% women) aged 67.3 ± 6.0 years, at high cardiovascular risk. Diet was assessed at the study baseline using a validated, semi-quantitative food frequency questionnaire. Results: During the follow-up period 131 diabetics were newly diagnosed. The risk of developing T2DM was assessed using baseline heme iron intake and proportional hazard models, first unadjusted, then adjusted for energy, and finally adjusted for dietary, anthropometric, socio-demographic and lifestyle variables. Significant direct associations with the incidence of T2DM were found for heme iron (Hazard Ratio [HR] 1.30, 95% confidence interval [CI], 1.02 to 1.66). Secondarily, we have also observed that coffee (HR:0.93, 95% CI, 0.89 to 0.98) and alcoholic beverages (HR: 1.02, 95% CI, 1.01 to 1.04) were also found to reduce and increase the risk of T2DM, respectively. Conclusion: High dietary intake of heme iron was associated with an increased risk of developing T2DM in a Mediterranean population at high cardiovascular risk. Trial registration. Identifier: ISRCTN35739639. © 2013 Fernandez-Cao et al.; licensee BioMed Central Ltd.
Thematic Areas: Zootecnia / recursos pesqueiros Sociología Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Ensino Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Astronomia / física Antropologia / arqueologia Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14712458
Author's mail: josep.basora@urv.cat nuria.aranda@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0001-9708-747X 0000-0002-0218-7046 0000-0003-2700-7459 0000-0002-1758-0975
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-13-1042
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Public Health. 13 (1): 1042-
APA: Candido Fernandez-Cao, Jose; Arija, Victoria; Aranda, Nuria; Bullo, Monica; Basora, Josep; Angel Martinez-Gonzalez, Miguel; Diez-Espino, Javier; Salas (2013). Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: An observational cohort analysis. Bmc Public Health, 13(1), 1042-. DOI: 10.1186/1471-2458-13-1042
Article's DOI: 10.1186/1471-2458-13-1042
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications
Repositori URV