Author, as appears in the article.: Rojo-Martínez G; Maymó-Masip E; Mar Rodríguez M; Solano E; Goday A; Soriguer F; Valdés S; Chaves F; Delgado E; Colomo N; Hernández P; Vendrell J; Chacón M
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Chacón Navarro, María Gema / Maymo Masip, Elsa / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
Keywords: Weight-loss Weak inducer Tweak Tnf-alpha Soluble cd163 Obesity Metabolic syndrome Mediterranean diet Inflammation High cardiovascular risk
Abstract: Objective: Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study. Research Design and Methods: This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. Results: sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively). Conclusions: High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes. © 2014 Rojo-Martínez et al.
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licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Author's mail: elsa.maymo@urv.cat mariagema.chacon@urv.cat juanjose.vendrell@urv.cat
Author identifier: 0000-0002-9133-3120 0000-0002-6994-6115
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101250
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Plos One. 9 (6): e101250-
APA: Rojo-Martínez G; Maymó-Masip E; Mar Rodríguez M; Solano E; Goday A; Soriguer F; Valdés S; Chaves F; Delgado E; Colomo N; Hernández P; Vendrell J; Chac (2014). Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: Results of the di@bet.es study. Plos One, 9(6), e101250-. DOI: 10.1371/journal.pone.0101250
Article's DOI: 10.1371/journal.pone.0101250
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications