Author, as appears in the article.: Masana L; Cabré A; Heras M; Amigó N; Correig X; Martínez-Hervás S; Real J; Ascaso J; Quesada H; Julve J; Palomer X; Vázquez-Carrera M; Girona J; Plana N; Blanco-Vaca F

Department: Medicina i Cirurgia Enginyeria Electrònica, Elèctrica i Automàtica Ciències Mèdiques Bàsiques

URV's Author/s: CABRÉ LLOBET, ANNA / Correig Blanchar, Francesc Xavier / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / Masana Marín, Luis / Plana Gil, Núria

Keywords: Type 2 diabetes Preβ1-hdl Pre?1-hdl Pon3 Pon1 Paf-ah Nuclear magnetic resonance Niacin Lcat Hdl particle size Hdl Fenofibrate Cetp pre?1-hdl pon3 pon1 paf-ah nuclear magnetic resonance niacin lcat hdl particle size hdl fenofibrate cetp

Abstract: © 2014 Elsevier Ireland Ltd. HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes. Drug-mediated quantitative and qualitative HDL modifications could be involved in these negative results. To evaluate the quantitative and qualitative effects of niacin and fenofibrate on HDL in patients with type 2 diabetes, a prospective, randomised controlled intervention trial was conducted. Thirty type 2 diabetic patients with low HDL were randomised to receive either fenofibrate (FFB) or niacin+laropiprant (ERN/LPR) as an add-on to simvastatin treatment for 12 weeks according to a crossover design. At the basal point and after each intervention period, physical examinations and comprehensive standard biochemical determinations and HDL metabolomics were performed. Thirty nondiabetic patients with normal HDL were used as a basal control group. ERN/LRP, but not FFB, significantly increased HDL cholesterol. Neither ERN/LRP nor FFB reversed the HDL particle size or particle number to normal. ERN/LRP increased apoA-I but not apoA-II, whereas FFB produced the opposite effect. FFB significantly increased Preβ1-HDL, whereas ERN/LRP tended to lower Preβ1-HDL. CETP and LCAT activities were significantly decreased only by ERN/LRP. PAF-AH activity in HDL and plasma decreased with the use of both agents. Despite their different actions on antioxidant parameters, none of the treatments induced detectable antioxidant improvements.ERN/LRP and FFB had strikingly different effects on HDL quantity and quality, as well as on HDL cholesterol concentrations. When prescribing HDL cholesterol increasing drugs, this differential action should be considered.

Thematic Areas: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00219150

Author's mail: xavier.correig@urv.cat josefa.girona@urv.cat nuria.plana@urv.cat luis.masana@urv.cat josefa.girona@urv.cat

Author identifier: 0000-0002-6902-3054 0000-0002-6267-8779 0000-0002-4231-7618 0000-0002-0789-4954 0000-0002-6267-8779

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.atherosclerosis-journal.com/article/S0021-9150(14)01612-8/fulltext#%20

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Atherosclerosis. 238 (2): 213-219

APA: Masana L; Cabré A; Heras M; Amigó N; Correig X; Martínez-Hervás S; Real J; Ascaso J; Quesada H; Julve J; Palomer X; Vázquez-Carrera M; Girona J; Plana (2015). Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients. Atherosclerosis, 238(2), 213-219. DOI: 10.1016/j.atherosclerosis.2014.12.006

Article's DOI: 10.1016/j.atherosclerosis.2014.12.006

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications