Author, as appears in the article.: García-Minguillán C; Fernandez-Ballart J; Ceruelo S; Ríos L; Bueno O; Berrocal-Zaragoza M; Molloy A; Ueland P; Meyer K; Murphy M
Department: Ciències Mèdiques Bàsiques
URV's Author/s: BERROCAL ZARAGOZA, MA. ISABEL / CERUELO CARO, SANTIAGO / Fernández Ballart, Joan Domènech / GARCIA MINGUILLÁN DEL CAMPO, CARLOS JESÚS / Murphy, Michelle
Keywords: Vitamin b6 Riboflavin Mtrr Mthfr Homocysteine Egrac Eastac
Abstract: © 2014, Springer-Verlag Berlin Heidelberg. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524C>T polymorphisms on homocysteine are unclear. We tested the hypothesis that the effects of the MTHFR 677C>T, MTRR 66A>G and MTRR 524C>T polymorphisms on fasting plasma total homocysteine (tHcy) depend on riboflavin status (erythrocyte glutathionine reductase activation coefficient, optimum: <1.2; marginally deficient: 1.2–1.4; deficient: ≥1.4) in 771 adults aged 18–75 years. MTHFR 677T allele carriers with middle or low tertile plasma folate (<14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p < 0.01). This effect was eliminated when riboflavin status was optimal (p for interaction: 0.048). In the lowest cobalamin quartile (≤273 pmol/L), riboflavin status modifies the relationship between the MTRR 66 A>G polymorphism and tHcy (p for interaction: 0.034). tHcy was 6.6 % higher in MTRR 66G allele carriers compared to the 66AA genotype with marginally deficient or optimal riboflavin status, but there was no difference when riboflavin status was deficient (p for interaction: 0.059). tHcy was 13.7 % higher in MTRR 524T allele carriers compared to the 524CC genotype when cobalamin status was low (p < 0.01), but no difference was observed when we stratified by riboflavin status. The effect of the MTHFR 677C>T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A>G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C>T polymorphism on cobalamin status.
Thematic Areas: Zootecnia / recursos pesqueiros Nutrition & dietetics Nutrição Medicina ii Medicina i Interdisciplinar Genetics & heredity Genetics Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 15558932
Author's mail: michelle.murphy@urv.cat
Author identifier: 0000-0002-6304-6204
Record's date: 2023-12-16
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s12263-014-0435-1#citeas
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Genes And Nutrition. 9 (6):
APA: García-Minguillán C; Fernandez-Ballart J; Ceruelo S; Ríos L; Bueno O; Berrocal-Zaragoza M; Molloy A; Ueland P; Meyer K; Murphy M (2014). Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine. Genes And Nutrition, 9(6), -. DOI: 10.1007/s12263-014-0435-1
Article's DOI: 10.1007/s12263-014-0435-1
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV