Author, as appears in the article.: Hernández-Alonso P; Salas-Salvadó J; Baldrich-Mora M; Mallol R; Correig X; Bulló M

Department: Enginyeria Electrònica, Elèctrica i Automàtica Bioquímica i Biotecnologia

URV's Author/s: Bulló Bonet, Mònica / Correig Blanchar, Francesc Xavier / MALLOL PARERA, ROGER / Salas Salvadó, Jorge

Keywords: Pre-diabetes Pistachios Lipoprotein Dietary intervention Clinical trial Cardiovascular disease pistachios lipoprotein dietary intervention clinical trial cardiovascular disease

Abstract: © 2015 Elsevier B.V. Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.

Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 15903729

Author's mail: xavier.correig@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat

Author identifier: 0000-0002-6902-3054 0000-0003-2700-7459 0000-0002-0218-7046

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.nmcd-journal.com/article/S0939-4753(15)00031-9/fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 25 (4): 396-402

APA: Hernández-Alonso P; Salas-Salvadó J; Baldrich-Mora M; Mallol R; Correig X; Bulló M (2015). Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects. Nutrition Metabolism And Cardiovascular Diseases, 25(4), 396-402. DOI: 10.1016/j.numecd.2015.01.013

Article's DOI: 10.1016/j.numecd.2015.01.013

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications