Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects

  • Identification data

    Identifier: imarina:6388228
    Authors:
    Hernandez-Alonso, PSalas-Salvado, JBaldrich-Mora, MMallol, RCorreig, XBullo, M
    Abstract:
    © 2015 Elsevier B.V. Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.
  • Others:

    Author, as appears in the article.: Hernandez-Alonso, P; Salas-Salvado, J; Baldrich-Mora, M; Mallol, R; Correig, X; Bullo, M
    Department: Enginyeria Electrònica, Elèctrica i Automàtica Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Correig Blanchar, Francesc Xavier / MALLOL PARERA, ROGER / Salas Salvadó, Jorge
    Keywords: Pre-diabetes Pistachios Lipoprotein Dietary intervention Clinical trial Cardiovascular disease pistachios lipoprotein dietary intervention clinical trial cardiovascular disease
    Abstract: © 2015 Elsevier B.V. Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.
    Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15903729
    Author's mail: monica.bullo@urv.cat xavier.correig@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0002-6902-3054 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.nmcd-journal.com/article/S0939-4753(15)00031-9/fulltext
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 25 (4): 396-402
    APA: Hernandez-Alonso, P; Salas-Salvado, J; Baldrich-Mora, M; Mallol, R; Correig, X; Bullo, M (2015). Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects. Nutrition Metabolism And Cardiovascular Diseases, 25(4), 396-402. DOI: 10.1016/j.numecd.2015.01.013
    Article's DOI: 10.1016/j.numecd.2015.01.013
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Pre-diabetes
    Pistachios
    Lipoprotein
    Dietary intervention
    Clinical trial
    Cardiovascular disease
    pistachios
    lipoprotein
    dietary intervention
    clinical trial
    cardiovascular disease
    Serviço social
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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