Articles producció científica> Medicina i Cirurgia

Diagnosis of non-celiac gluten sensitivity (NCGS): The salerno experts’ criteria

  • Identification data

    Identifier: imarina:6388238
    Authors:
    Catassi CElli LBonaz BBouma GCarroccio ACastillejo GCellier CCristofori Fde Magistris LDolinsek JDieterich WFrancavilla RHadjivassiliou MHoltmeier WKörner ULeffler DALundin KEAMazzarella GMulder CJPellegrini NRostami KSanders DSkodje GISchuppan DUllrich RVolta UWilliams MZevallos VFZopf YFasano A
    Abstract:
    © 2015 by the authors; licensee MDPI, Basel, Switzerland. Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease or wheat allergy. Given the lack of a NCGS biomarker, there is the need for standardizing the procedure leading to the diagnosis confirmation. In this paper we report experts’ recommendations on how the diagnostic protocol should be performed for the confirmation of NCGS. A full diagnostic procedure should assess the clinical response to the gluten-free diet (GFD) and measure the effect of a gluten challenge after a period of treatment with the GFD. The clinical evaluation is performed using a self-administered instrument incorporating a modified version of the Gastrointestinal Symptom Rating Scale. The patient identifies one to three main symptoms that are quantitatively assessed using a Numerical Rating Scale with a score ranging from 1 to 10. The double-blind placebo-controlled gluten challenge (8 g/day) includes a one-week challenge followed by a one-week washout of strict GFD and by the crossover to the second one-week challenge. The vehicle should contain cooked, homogeneously distributed gluten. At least a variation of 30% of one to three main symptoms between the gluten and the placebo challenge should be detected to discriminate a positive from a negative result. The guidelines provided in this paper will help the clinician to reach a firm and positive diagnosis of NCGS and facilitate the comparisons of different studies, if adopted internationally.
  • Others:

    Author, as appears in the article.: Catassi C; Elli L; Bonaz B; Bouma G; Carroccio A; Castillejo G; Cellier C; Cristofori F; de Magistris L; Dolinsek J; Dieterich W; Francavilla R; Hadjivassiliou M; Holtmeier W; Körner U; Leffler DA; Lundin KEA; Mazzarella G; Mulder CJ; Pellegrini N; Rostami K; Sanders D; Skodje GI; Schuppan D; Ullrich R; Volta U; Williams M; Zevallos VF; Zopf Y; Fasano A
    Department: Medicina i Cirurgia
    URV's Author/s: Castillejo De Villasante, Gemma
    Keywords: Non-celiac gluten sensitivity Irritable bowel syndrome Gastrointestinal symptom rating scale Double-blind placebo-controlled challenge Diagnosis irritable bowel syndrome gastrointestinal symptom rating scale double-blind placebo-controlled challenge diagnosis
    Abstract: © 2015 by the authors; licensee MDPI, Basel, Switzerland. Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease or wheat allergy. Given the lack of a NCGS biomarker, there is the need for standardizing the procedure leading to the diagnosis confirmation. In this paper we report experts’ recommendations on how the diagnostic protocol should be performed for the confirmation of NCGS. A full diagnostic procedure should assess the clinical response to the gluten-free diet (GFD) and measure the effect of a gluten challenge after a period of treatment with the GFD. The clinical evaluation is performed using a self-administered instrument incorporating a modified version of the Gastrointestinal Symptom Rating Scale. The patient identifies one to three main symptoms that are quantitatively assessed using a Numerical Rating Scale with a score ranging from 1 to 10. The double-blind placebo-controlled gluten challenge (8 g/day) includes a one-week challenge followed by a one-week washout of strict GFD and by the crossover to the second one-week challenge. The vehicle should contain cooked, homogeneously distributed gluten. At least a variation of 30% of one to three main symptoms between the gluten and the placebo challenge should be detected to discriminate a positive from a negative result. The guidelines provided in this paper will help the clinician to reach a firm and positive diagnosis of NCGS and facilitate the comparisons of different studies, if adopted internationally.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Author's mail: gemma.castillejo@urv.cat
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/7/6/4966
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 7 (6): 4966-4977
    APA: Catassi C; Elli L; Bonaz B; Bouma G; Carroccio A; Castillejo G; Cellier C; Cristofori F; de Magistris L; Dolinsek J; Dieterich W; Francavilla R; Hadji (2015). Diagnosis of non-celiac gluten sensitivity (NCGS): The salerno experts’ criteria. Nutrients, 7(6), 4966-4977. DOI: 10.3390/nu7064966
    Article's DOI: 10.3390/nu7064966
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Non-celiac gluten sensitivity
    Irritable bowel syndrome
    Gastrointestinal symptom rating scale
    Double-blind placebo-controlled challenge
    Diagnosis
    irritable bowel syndrome
    gastrointestinal symptom rating scale
    double-blind placebo-controlled challenge
    diagnosis
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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