Author, as appears in the article.: Saballs, M; Parra, S; Sahun, P; Pellejà, J; Feliu, M; Vasco, C; Gumà, J; Borràs, JL; Masana, L; Castro, A
Department: Medicina i Cirurgia
URV's Author/s: BORRAS BALADA, JOAN LLUÍS / Castro Salomó, Antoni / Feliu Masgoret, Mireia / Gumà Padró, José / Masana Marín, Luis / Parra Pérez, Sandra / Pelleja Carnasa, Joan / Vasco Lopez, Carlos Arturo
Keywords: Statins Simvastatin Severity Severe sepsis Rule Pleural effusion Mechanisms Inhibitors Inflammatory responses Hdl Disease Community-acquired pneumonia Cholesterol
Abstract: © 2016, The Author(s). Objectives: To investigate if HDL cholesterol (HDL-c) could be a biomarker of the degree of severity according to prognostic prediction scores in community-acquired pneumonia (CAP) or the development of clinical complications such as pleural effusion. Methods: We included in a retrospective study 107 patients admitted to the hospital that fulfilled diagnostic criteria for CAP between the 30th October 2011 and 1st September 2012. HDL-c levels at admission, CAP prognosis scores (PSI and CURB65) and clinical outcomes were recorded for the study. Results: Basal HDL-c levels were not statistically different according to prognostics scores neither PSI nor CURB-65. Significantly lower levels of HDL-c were also associated to the development of septic shock and admission to the intensive care unit. HDL-c were inversely correlated with acute phase reactants CRP (r = −0.585, P < 0.001), ESR (r = −0.477, P < 0.001), and leukocytes cell count (r = −0.254, P < 0.009). Patients with pleural effusion showed significant lower levels of HDL-c [28.9 (15.5) mg/dl vs. 44.6 (21.1) mg/dl]; P = 0.007. HDL-c is a good predictor of the presence of pleural effusion in multivariate analyses and using ROC analyses [AUC = 0.712 (0.591–0.834), P = 0.006]. HDL-c levels of 10 mg/dl showed a sensitivity of 97.6 % and a specificity of 82.4 % for the presence of pleural effusion. Conclusion: Monitoring HDL-c in CAP is an useful serum marker of acute phase response, clinical outcome and the presence of pleural effusion.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 21931801
Author's mail: carlosarturo.vasco@urv.cat joan.pelleja@urv.cat mireia.feliu@urv.cat luis.masana@urv.cat antoni.castro@urv.cat jose.guma@urv.cat sandra.parra@urv.cat
Author identifier: 0000-0002-0789-4954 0000-0001-5441-6333 0000-0001-7541-9832 0000-0001-9363-6574
Record's date: 2024-01-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://springerplus.springeropen.com/articles/10.1186/s40064-016-3145-x
Papper original source: Springerplus. 5 (1): 1491-
APA: Saballs, M; Parra, S; Sahun, P; Pellejà, J; Feliu, M; Vasco, C; Gumà, J; Borràs, JL; Masana, L; Castro, A (2016). HDL-c levels predict the presence of pleural effusion and the clinical outcome of community-acquired pneumonia. Springerplus, 5(1), 1491-. DOI: 10.1186/s40064-016-3145-x
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1186/s40064-016-3145-x
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV