Author, as appears in the article.: Miguel Baena-Diez, Jose; Penafiel, Judit; Subirana, Isaac; Ramos, Rafel; Elosua, Roberto; Marin-Ibanez, Alejandro; Jesus Guembe, Maria; Rigo, Fernando; Jose Tormo-Diaz, Maria; Moreno-Iribas, Conchi; Josep Cabre, Joan; Segura, Antonio; Garcia-Lareo, Manel; Gomez de la Carnara, Agustin; Lapetra, Jose; Quesada, Miguel; Marrugat, Jaume; Jose Medrano, Maria; Berjon, Jesus; Frontera, Guiem; Gavrila, Diana; Barricarte, Aurelio; Basora, Josep; Maria Garcia, Jose; Pavone, Natalia C; Lora-Pablos, David; Mayora, Eduardo; Franch, Josep; Mata, Manel; Castell, Conxa; Frances, Albert; Grau, Maria
Department: Medicina i Cirurgia
URV's Author/s: Basora Gallisa, Josep / Cabré Olivé, Joan / Cabre Vila, Juan Jose
Keywords: Myocardial-infarction Mortality Metaanalysis Mellitus Hazards Glucose Coronary-heart-disease Complications Cardiovascular risk All-cause
Abstract: © 2016 by the American Diabetes Association. OBJECTIVE Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) inmen; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular noncancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) inmen; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes.
Thematic Areas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01495992
Author's mail: juanjose.cabre@urv.cat josep.basora@urv.cat josep.basora@urv.cat
Author identifier: 0000-0003-1082-6861
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://care.diabetesjournals.org/content/39/11/1987
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Diabetes Care. 39 (11): 1987-1995
APA: Miguel Baena-Diez, Jose; Penafiel, Judit; Subirana, Isaac; Ramos, Rafel; Elosua, Roberto; Marin-Ibanez, Alejandro; Jesus Guembe, Maria; Rigo, Fernando (2016). Risk of cause-specific death in individuals with diabetes: A competing risks analysis. Diabetes Care, 39(11), 1987-1995. DOI: 10.2337/dc16-0614
Article's DOI: 10.2337/dc16-0614
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV