Articles producció científica> Ciències Mèdiques Bàsiques

Presynaptic membrane receptors modulate ACh release, axonal competition and synapse elimination during neuromuscular junction development

  • Identification data

    Identifier: imarina:6389168
    Authors:
    Tomas, JosepGarcia, NeusLanuza, Maria ASantafe, Manel MTomas, MartaNadal, LauraHurtado, EricaSimo, AnnaCilleros, Victor
    Abstract:
    © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.
  • Others:

    Author, as appears in the article.: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo, Anna; Cilleros, Victor
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Hurtado Caballero, Erica / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / Santafé Martínez, Manuel / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta
    Keywords: Voltage-dependent calcium channels Trkb Protein kinases Postnatal synapse elimination Pkc Muscarinic acetylcholine receptors Axonal competition Acetylcholine release trkb protein kinases postnatal synapse elimination pkc muscarinic acetylcholine receptors axonal competition acetylcholine release
    Abstract: © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.
    Thematic Areas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16625099
    Author's mail: marta.tomas@urv.cat erica.hurtado@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat
    Author identifier: 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-4795-4103 0000-0002-5462-5108
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fnmol.2017.00132/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Molecular Neuroscience. 10 132-
    APA: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo, Anna; Cilleros, Victor (2017). Presynaptic membrane receptors modulate ACh release, axonal competition and synapse elimination during neuromuscular junction development. Frontiers In Molecular Neuroscience, 10(), 132-. DOI: 10.3389/fnmol.2017.00132
    Article's DOI: 10.3389/fnmol.2017.00132
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Cellular and Molecular Neuroscience,Molecular Biology,Neurosciences
    Voltage-dependent calcium channels
    Trkb
    Protein kinases
    Postnatal synapse elimination
    Pkc
    Muscarinic acetylcholine receptors
    Axonal competition
    Acetylcholine release
    trkb
    protein kinases
    postnatal synapse elimination
    pkc
    muscarinic acetylcholine receptors
    axonal competition
    acetylcholine release
    Neurosciences
    Molecular biology
    Medicina ii
    Ciências biológicas ii
    Cellular and molecular neuroscience
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