Author, as appears in the article.: Torres-Fuentes, Cristina; Schellekens, Harriet; Dinan, Timothy G; Cryan, John F
Department: Bioquímica i Biotecnologia
URV's Author/s: Torres Fuentes, Cristina
Keywords: Zero hunger; Reward; Probiotics; Prebiotics; Obesity; Metagenomics; Humans; Gastrointestinal microbiome; Feeding behavior; Fecal microbiota transplantation; Energy metabolism; Diet, reducing; Brain; Appetite regulation; Affect
Abstract: © 2017 Elsevier Ltd Changes in microbial diversity and composition are increasingly associated with several disease states including obesity and behavioural disorders. Obesity-associated microbiota alter host energy harvesting, insulin resistance, inflammation, and fat deposition. Additionally, intestinal microbiota can regulate metabolism, adiposity, homoeostasis, and energy balance as well as central appetite and food reward signalling, which together have crucial roles in obesity. Moreover, some strains of bacteria and their metabolites might target the brain directly via vagal stimulation or indirectly through immune-neuroendocrine mechanisms. Therefore, the gut microbiota is becoming a target for new anti-obesity therapies. Further investigations are needed to elucidate the intricate gut-microbiota–host relationship and the potential of gut-microbiota-targeted strategies, such as dietary interventions and faecal microbiota transplantation, as promising metabolic therapies that help patients to maintain a healthy weight throughout life.
Thematic Areas: Hepatology; Gastroenterology & hepatology; Gastroenterology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 24681253
Author's mail: cristina.torres@urv.cat
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S2468125317301474
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Lancet Gastroenterology & Hepatology. 2 (10): 747-756
APA: Torres-Fuentes, Cristina; Schellekens, Harriet; Dinan, Timothy G; Cryan, John F (2017). The microbiota–gut–brain axis in obesity. Lancet Gastroenterology & Hepatology, 2(10), 747-756. DOI: 10.1016/S2468-1253(17)30147-4
Article's DOI: 10.1016/S2468-1253(17)30147-4
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV