Articles producció científica> Enginyeria Química

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

  • Identification data

    Identifier: imarina:6389873
    Authors:
    Ammendola MHaponska MBalik KModrakowska PMatulewicz KKazmierski LLis AKozlowska JGarcia-Valls RGiamberini MBajek ATylkowski B
    Abstract:
    © 2020, The Author(s). The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry.
  • Others:

    Author, as appears in the article.: Ammendola M; Haponska M; Balik K; Modrakowska P; Matulewicz K; Kazmierski L; Lis A; Kozlowska J; Garcia-Valls R; Giamberini M; Bajek A; Tylkowski B
    Department: Enginyeria Química
    URV's Author/s: Garcia Valls, Ricard / Giamberini, Marta / Tylkowski, Bartosz
    Keywords: Temperature Prevention Polyphenols Mechanisms In-vitro Chitosan Antioxidant activity
    Abstract: © 2020, The Author(s). The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2045-2322
    Author's mail: bartosz.tylkowski@urv.cat ricard.garcia@urv.cat marta.giamberini@urv.cat
    Author identifier: 0000-0002-4163-0178 0000-0002-3945-0434 0000-0001-8278-3552
    Record's date: 2023-02-19
    Journal volume: 10
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-020-63444-3
    Papper original source: Scientific Reports. 10 (1): 6521-
    APA: Ammendola M; Haponska M; Balik K; Modrakowska P; Matulewicz K; Kazmierski L; Lis A; Kozlowska J; Garcia-Valls R; Giamberini M; Bajek A; Tylkowski B (2020). Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments. Scientific Reports, 10(1), 6521-. DOI: 10.1038/s41598-020-63444-3
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1038/s41598-020-63444-3
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Temperature
    Prevention
    Polyphenols
    Mechanisms
    In-vitro
    Chitosan
    Antioxidant activity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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