Author, as appears in the article.: Lara, Pedro C.; Nguyen, Nam P.; Macias-Verde, David; Burgos-Burgos, Javier; Arenas, Meritxell; Zamagni, Alice; Vinh-Hung, Vincent; Baumert, Brigitta G.; Motta, Micaela; Myint, Arthur Sun; Bonet, Marta; Popescu, Tiberiu; Te Vuong; Appalanaido, Gokula Kumar; Trigo, Lurdes; Karlsson, Ulf; Thariat, Juliette;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arenas Prat, Meritxell
Keywords: X-rays Treatment Sars-cov 2 Roentgen therapy Ldrt Inflammation Infections Historical use Elderly
Abstract: A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Low dose total lung (LDTL) irradiation at a single dose of 50 cGy may stop this cytokine cascade, thus preventing, and/or reversing normal organs damage. This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation - induced malignancy is not a concern because of their advanced age. This hypothesis should be tested in future prospective trials.
Thematic Areas: Psicología Pathology and forensic medicine Neurology (clinical) Medicina ii Medicina i Interdisciplinar Geriatrics and gerontology Geriatrics & gerontology Educação física Ciências biológicas ii Cell biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: meritxell.arenas@urv.cat
Author identifier: 0000-0003-0815-2570
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: http://www.aginganddisease.org/EN/10.14336/AD.2020.0506#1
Papper original source: Aging And Disease. 11 (3): 489-493
APA: Lara, Pedro C.; Nguyen, Nam P.; Macias-Verde, David; Burgos-Burgos, Javier; Arenas, Meritxell; Zamagni, Alice; Vinh-Hung, Vincent; Baumert, Brigitta G (2020). Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group. Aging And Disease, 11(3), 489-493. DOI: 10.14336/AD.2020.0506
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.14336/AD.2020.0506
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV