Author, as appears in the article.: Parody, Rocio; Sanchez-Ortega, Isabel; Ferra, Christelle; Guardia, Ramon; Talarn, Carme; Encuentra, Maite; Fort, Eduard; Lopez, David; Morgades, Mireia; Alonso, Eva; Ortega, Sandra; Sarra, Josep; Gallardo, David; Ribera, Josep M.; Sureda, Anna;

Department: Medicina i Cirurgia

URV's Author/s: Sarra Escarre, Jose

Keywords: Stem cell mobilization Prophylaxis Profiles Preemptive plerixafor Plerixafor Multiple-myeloma Lymphoma G-csf Combination Colony-stimulating factor Collection Chemotherapy-induced neutropenia Biosimilars plerixafor biosimilars

Abstract: Introduction Biosimilars of granulocyte colony-stimulating factors (G-CSF) have shown similar efficacy to originator filgrastim (Neupogen (R) [NEU]; Amgen Inc.) as prophylaxis in neutropenia and in the mobilization of stem cells in patients receiving combination chemotherapy with G-CSF. Methods This was a retrospective study in which the characteristics of stem cell mobilization treated with a G-CSF alone were compared in 216 patients and 56 donors. The two G-CSF compared were NEU and the biosimilar filgrastim Zarzio (R) (Sandoz GmbH) (referred to hereafter as BIO). Primary objectives were mobilization rate (minimum of 10 x 10(3)/ml CD34+ on day 4 of treatment [day +4]) and use of the immunostimulant plerixafor (PLEX) in each group. Results The general characteristics of the patients receiving NEU (n = 138) and those receiving BIO (n = 78) did not differ significantly. PLEX was used in 24% of BIO patients and in 25.7% of NEU patients. The median CD34+ cell count on day +4 was significantly lower in BIO patients who needed PLEX than in those who did not (2.4 vs. 4.8 x 10(3)/ml; p = 0.002), as was the final CD34+ cell count (2.5 vs. 3.3 x 10(6)/kg; p 0.03). Mobilization failure rate was higher in the BIO group than in the NEU group (20 vs. 0%; p = 0.01). With respect to donors, more than one apheresis was needed in three BIO donors, one of them with PLEX. The use of BIO was the only risk factor for mobilization failure in patients who needed PLEX (hazard ratio 10.3; 95% confidence interval 1.3-77.8). Conclusion The study revealed that BIO had a lower efficacy for stem cell mobilization when the only treatment was G-CSF, especially in poor mobilizers needing PLEX.

Thematic Areas: Oncology

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jose.sarra@urv.cat

Record's date: 2021-10-17

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://link.springer.com/article/10.1007%2Fs40487-020-00115-3#Sec11

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Oncology And Therapy. 8 (2): 311-324

APA: Parody, Rocio; Sanchez-Ortega, Isabel; Ferra, Christelle; Guardia, Ramon; Talarn, Carme; Encuentra, Maite; Fort, Eduard; Lopez, David; Morgades, Mirei (2020). Mobilization of Hematopoietic Stem Cells into Peripheral Blood for Autologous Transplantation Seems Less Efficacious in Poor Mobilizers with the Use of a Biosimilar of Filgrastim and Plerixafor: A Retrospective Comparative Analysis. Oncology And Therapy, 8(2), 311-324. DOI: 10.1007/s40487-020-00115-3

Article's DOI: 10.1007/s40487-020-00115-3

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications