Author, as appears in the article.: Martin-Loeches I, Papiol E, Rodríguez A, Diaz E, Zaragoza R, Granada RM, Socias L, Bonastre J, Valverdú M, Pozo JC, Luque P, Juliá-Narvaéz JA, Cordero L, Albaya A, Serón D, Rello J, H1N1 SEMICYUC Working Group

Department: Medicina i Cirurgia

URV's Author/s: Cabre Vila, Juan Jose / Rello Condomines, Jordi / Rodríguez Oviedo, Alejandro Hugo

Abstract: Little information exists about the impact of acute kidney injury (AKI) in critically ill patients with the pandemic 2009 influenza A (H1N1) virus infection.We conducted a prospective, observational, multicenter study in 148 Spanish intensive care units (ICUs). Patients with chronic renal failure were excluded. AKI was defined according to Acute Kidney Injury Network (AKIN) criteria.A total of 661 patients were analyzed. One hundred eighteen (17.7%) patients developed AKI; of these, 37 (31.4%) of the patients with AKI were classified as AKI I, 15 (12.7%) were classified as AKI II and 66 (55.9%) were classified as AKI III, among the latter of whom 50 (75.7%) required continuous renal replacement therapy. Patients with AKI had a higher Acute Physiology and Chronic Health Evaluation II score (19.2 ± 8.3 versus 12.6 ± 5.9; P < 0.001), a higher Sequential Organ Failure Assessment score (8.7 ± 4.2 versus 4.8 ± 2.9; P < 0.001), more need for mechanical ventilation (MV) (87.3% versus 56.2%; P < 0.01, odds ratio (OR) 5.3, 95% confidence interval (CI) 3.0 to 9.4), a greater incidence of shock (75.4% versus 38.3%; P < 0.01, OR 4.9, 95% CI, 3.1 to 7.7), a greater incidence of multiorgan dysfunction syndrome (92.4% versus 54.7%; P < 0.01, OR 10.0, 95% CI, 4.9 to 20.21) and a greater incidence of coinfection (23.7% versus 14.4%; P < 0.01, OR 1.8, 95% CI, 1.1 to 3.0). In survivors, patients with AKI remained on MV longer and ICU and hospital length of stay were longer than in patients without AKI. The overall mortality was 18.8% and was significantly higher for AKI patients (44.1% versus 13.3%; P < 0.01, OR 5.1, 95% CI, 3.3 to 7.9). Logistic regression analysis was performed with AKIN criteria, and it demonstrated that among patients with AKI, only AKI III was independently associated with higher ICU mortality (P < 0.001, OR 4.81, 95% CI 2.17 to 10.62).In our cohort of patients with H1N1 virus infection, only those cases in the AKI III category were independently associated with mortality.© 2011 Martín-Loeches et al.; licensee BioMed Central Ltd.

Thematic Areas: Saúde coletiva Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iv Enfermagem Educação física Critical care medicine Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1466-609X

Author's mail: juanjose.cabre@urv.cat alejandrohugo.rodriguez@urv.cat

Author identifier: 0000-0003-1082-6861 0000-0001-8828-5984

Record's date: 2023-09-02

Journal volume: 15

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://ccforum.biomedcentral.com/articles/10.1186/cc10046

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Critical Care. 15 (1): R66-R66

APA: Martin-Loeches I, Papiol E, Rodríguez A, Diaz E, Zaragoza R, Granada RM, Socias L, Bonastre J, Valverdú M, Pozo JC, Luque P, Juliá-Narvaéz JA, Cordero (2011). Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection. Critical Care, 15(1), R66-R66. DOI: 10.1186/cc10046

Article's DOI: 10.1186/cc10046

Entity: Universitat Rovira i Virgili

Journal publication year: 2011

Publication Type: Journal Publications